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ChEMBL

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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL4191
Target Type SINGLE PROTEIN
Preferred Name Monoglyceride lipase
Synonyms HU-K5 | Lysophospholipase homolog | Lysophospholipase-like | MAGL | MGL | MGLL | Monoacylglycerol lipase | Monoglyceride lipase
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme

Target Components

Component Description Relationship Accession
Monoglyceride lipase SINGLE PROTEIN Q99685

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000074416
Ensembl ENSG00000074416
GO Cellular Component GO:0005654 (nucleoplasm)
GO:0005737 (cytoplasm)
GO:0005789 (endoplasmic reticulum membrane)
GO:0005829 (cytosol)
GO:0005886 (plasma membrane)
GO:0016020 (membrane)
GO:0019898 (extrinsic component of membrane)
GO Molecular Function GO:0004622 (lysophospholipase activity)
GO:0016787 (hydrolase activity)
GO:0042803 (protein homodimerization activity)
GO:0047372 (acylglycerol lipase activity)
GO:0052689 (carboxylic ester hydrolase activity)
GO Biological Process GO:0006629 (lipid metabolic process)
GO:0006631 (fatty acid metabolic process)
GO:0006633 (fatty acid biosynthetic process)
GO:0006954 (inflammatory response)
GO:0009966 (regulation of signal transduction)
GO:0016042 (lipid catabolic process)
GO:0019369 (arachidonic acid metabolic process)
GO:0019433 (triglyceride catabolic process)
GO:0036155 (acylglycerol acyl-chain remodeling)
GO:0046464 (acylglycerol catabolic process)
GO:0050727 (regulation of inflammatory response)
GO:0051930 (regulation of sensory perception of pain)
GO:2000124 (regulation of endocannabinoid signaling pathway)

Target Cross References - Protein

canSAR Q99685
Human Protein Atlas ENSG00000074416
IntAct Q99685
Guide to Pharmacology 1399
Open Targets ENSG00000074416
PharmGKB PA30789
Reactome R-HSA-1482883 (Acyl chain remodeling of DAG and TAG.)
R-HSA-163560 (Triglyceride catabolism.)
R-HSA-426048 (Arachidonate production from DAG.)
UniProt B3KRC2 B7Z9D1 Q6IBG9 Q96AA5 Q99685

Target Cross References - Domain

InterPro IPR000073 (AB_hydrolase_1.)
IPR022742 (Hydrolase_4.)
IPR029058 (AB_hydrolase.)
Pfam PF12146 (Hydrolase_4)

Target Cross References - Structure

PDBe 3HJU 3JW8 3JWE 3PE6 4UUQ 6AX1
CREDO 3HJU 3JW8 3JWE 3PE6 4UUQ 6AX1
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