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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL4187
Target Type SINGLE PROTEIN
Preferred Name Sodium channel protein type II alpha subunit
Synonyms HBSC II | NAC2 | SCN2A | SCN2A1 | SCN2A2 | Sodium channel protein brain II subunit alpha | Sodium channel protein type 2 subunit alpha | Sodium channel protein type II subunit alpha | Voltage-gated sodium channel subunit alpha Nav1.2
Organism Homo sapiens
Species Group No
Protein Target Classification
  • ion channel > voltage-gated ion channel > voltage-gated sodium channel

Target Components

Component Description Relationship Accession
Sodium channel protein type 2 subunit alpha SINGLE PROTEIN Q99250

Target Relations

ChEMBL ID Pref Name Target Type
CHEMBL2096682 Sodium channel alpha subunits; brain (Types I, II, III) PROTEIN FAMILY
CHEMBL2331043 Sodium channel alpha subunit PROTEIN FAMILY

Approved Drugs and Clinical Candidates

ChEMBL ID Name Mechanism of Action Max Phase References
CHEMBL29919 ELPETRIGINE Sodium channel protein type II alpha subunit blocker 0 PubMed PubMed

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000136531
Ensembl ENSG00000136531
GO Cellular Component GO:0001518 (voltage-gated sodium channel complex)
GO:0005622 (intracellular)
GO:0005886 (plasma membrane)
GO:0005887 (integral component of plasma membrane)
GO:0014704 (intercalated disc)
GO:0016020 (membrane)
GO:0016021 (integral component of membrane)
GO:0030315 (T-tubule)
GO:0030424 (axon)
GO:0031226 (intrinsic component of plasma membrane)
GO:0033268 (node of Ranvier)
GO:0033270 (paranode region of axon)
GO:0034706 (sodium channel complex)
GO Molecular Function GO:0005216 (ion channel activity)
GO:0005244 (voltage-gated ion channel activity)
GO:0005248 (voltage-gated sodium channel activity)
GO:0005272 (sodium channel activity)
GO Biological Process GO:0006810 (transport)
GO:0006811 (ion transport)
GO:0006814 (sodium ion transport)
GO:0007399 (nervous system development)
GO:0008627 (intrinsic apoptotic signaling pathway in response to osmotic stress)
GO:0019228 (neuronal action potential)
GO:0034765 (regulation of ion transmembrane transport)
GO:0035725 (sodium ion transmembrane transport)
GO:0042552 (myelination)
GO:0051402 (neuron apoptotic process)
GO:0055085 (transmembrane transport)
GO:0060078 (regulation of postsynaptic membrane potential)
GO:0086010 (membrane depolarization during action potential)
Wikipedia Nav1.2

Target Cross References - Protein

canSAR Q99250
CGD Epileptic encephalopathy, early infantile, 11; Seizures, benign familial infantile, 3
Human Protein Atlas ENSG00000136531
IntAct Q99250
Guide to Pharmacology 579
Open Targets ENSG00000136531
PharmGKB PA35004
Pharos Q99250 (Tclin)
Reactome R-HSA-445095 (Interaction between L1 and Ankyrins.)
R-HSA-5576892 (Phase 0 - rapid depolarisation.)
UniProt A6NC14 A6NIQ5 Q14472 Q53T77 Q99250 Q9BZC9 Q9BZD0

Target Cross References - Domain

InterPro IPR000048 (IQ_motif_EF-hand-BS.)
IPR001696 (Na_channel_asu.)
IPR005821 (Ion_trans_dom.)
IPR010526 (Na_trans_assoc.)
IPR024583 (Na_trans_cytopl.)
IPR027359 (Channel_four-helix_dom.)
Pfam PF00520 (Ion_trans)
PF06512 (Na_trans_assoc)
PF11933 (Na_trans_cytopl)

Target Cross References - Structure

PDBe 4JPZ
CREDO 4JPZ
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