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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL4165
Target Type SINGLE PROTEIN
Preferred Name DNA gyrase subunit A
Synonyms DNA gyrase subunit A | Type IIA topoisomerase subunit GyrA | gyrA
Organism Mycobacterium tuberculosis
Species Group No
Protein Target Classification
  • enzyme > isomerase

Target Components

Component Description Relationship Accession
DNA gyrase subunit A SINGLE PROTEIN P9WG47

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

GO Cellular Component GO:0005618 (cell wall)
GO:0005694 (chromosome)
GO:0005737 (cytoplasm)
GO:0005886 (plasma membrane)
GO Molecular Function GO:0000166 (nucleotide binding)
GO:0000287 (magnesium ion binding)
GO:0003677 (DNA binding)
GO:0003916 (DNA topoisomerase activity)
GO:0003918 (DNA topoisomerase type II (ATP-hydrolyzing) activity)
GO:0005515 (protein binding)
GO:0005524 (ATP binding)
GO:0016853 (isomerase activity)
GO:0016887 (ATPase activity)
GO:0034335 (DNA supercoiling activity)
GO:0061505 (DNA topoisomerase II activity)
GO Biological Process GO:0006259 (DNA metabolic process)
GO:0006265 (DNA topological change)
GO:0046677 (response to antibiotic)

Target Cross References - Protein

canSAR Q07702
UniProt J9VB15 P71574 P97136 P9WG47 Q07702

Target Cross References - Domain

InterPro IPR002205 (Topo_IIA_A/C.)
IPR005743 (GyrA.)
IPR006691 (GyrA/parC_rep.)
IPR013757 (Topo_IIA_A_a_sf.)
IPR013758 (Topo_IIA_A/C_ab.)
IPR013760 (Topo_IIA-like_dom_sf.)
IPR035516 (Gyrase/topoIV_suA_C.)
Pfam PF00521 (DNA_topoisoIV)
PF03989 (DNA_gyraseA_C)

Target Cross References - Structure

PDBe 3IFZ 3ILW 3UC1 4G3N 5BS8 5BTA 5BTC 5BTD 5BTF 5BTG 5BTI 5BTL 5BTN
CREDO 3IFZ 3ILW 3UC1 4G3N 5BS8 5BTA 5BTC 5BTD 5BTF 5BTG 5BTI 5BTL 5BTN
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