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Target Report Card

Target Name and Classification

Target ID CHEMBL4139
Preferred Name Tubulin alpha-1 chain
Synonyms Alpha-tubulin 1 | Detyrosinated tubulin alpha-1A chain | Tuba1 | Tuba1a | Tubulin alpha-1 chain | Tubulin alpha-1A chain
Organism Rattus norvegicus
Species Group No
Protein Target Classification
  • structural protein

Target Components

Component Description Relationship Accession
Tubulin alpha-1A chain SINGLE PROTEIN P68370

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

GO Cellular Component GO:0005737 (cytoplasm)
GO:0005856 (cytoskeleton)
GO:0005874 (microtubule)
GO:0005881 (cytoplasmic microtubule)
GO:0015630 (microtubule cytoskeleton)
GO:0036464 (cytoplasmic ribonucleoprotein granule)
GO:0043209 (myelin sheath)
GO:0045121 (membrane raft)
GO:0055037 (recycling endosome)
GO Molecular Function GO:0000166 (nucleotide binding)
GO:0003924 (GTPase activity)
GO:0005200 (structural constituent of cytoskeleton)
GO:0005515 (protein binding)
GO:0005525 (GTP binding)
GO:0019904 (protein domain specific binding)
GO:0046982 (protein heterodimerization activity)
GO Biological Process GO:0007010 (cytoskeleton organization)
GO:0007017 (microtubule-based process)

Target Cross References - Protein

canSAR P68370
IntAct P68370
Reactome R-RNO-190840 (Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane.)
R-RNO-2132295 (MHC class II antigen presentation.)
R-RNO-2467813 (Separation of Sister Chromatids.)
R-RNO-2500257 (Resolution of Sister Chromatid Cohesion.)
R-RNO-2565942 (Regulation of PLK1 Activity at G2/M Transition.)
R-RNO-3371497 (HSP90 chaperone cycle for steroid hormone receptors (SHR).)
R-RNO-380259 (Loss of Nlp from mitotic centrosomes.)
R-RNO-380270 (Recruitment of mitotic centrosome proteins and complexes.)
R-RNO-380320 (Recruitment of NuMA to mitotic centrosomes.)
R-RNO-437239 (Recycling pathway of L1.)
R-RNO-5610787 (Hedgehog 'off' state.)
R-RNO-5617833 (Cilium Assembly.)
R-RNO-5620912 (Anchoring of the basal body to the plasma membrane.)
R-RNO-5620924 (Intraflagellar transport.)
R-RNO-5626467 (RHO GTPases activate IQGAPs.)
R-RNO-5632684 (Hedgehog 'on' state.)
R-RNO-5663220 (RHO GTPases Activate Formins.)
R-RNO-6807878 (COPI-mediated anterograde transport.)
R-RNO-6811434 (COPI-dependent Golgi-to-ER retrograde traffic.)
R-RNO-6811436 (COPI-independent Golgi-to-ER retrograde traffic.)
R-RNO-68877 (Mitotic Prometaphase.)
R-RNO-8852276 (The role of GTSE1 in G2/M progression after G2 checkpoint.)
R-RNO-8854518 (AURKA Activation by TPX2.)
R-RNO-8955332 (Carboxyterminal post-translational modifications of tubulin.)
R-RNO-983189 (Kinesins.)
UniProt P02551 P05210 P05212 P68370 Q6P6G6

Target Cross References - Domain

InterPro IPR000217 (Tubulin.)
IPR002452 (Alpha_tubulin.)
IPR003008 (Tubulin_FtsZ_GTPase.)
IPR008280 (Tub_FtsZ_C.)
IPR017975 (Tubulin_CS.)
IPR018316 (Tubulin/FtsZ_2-layer-sand-dom.)
IPR023123 (Tubulin_C.)
IPR036525 (Tubulin/FtsZ_GTPase_sf.)
IPR037103 (Tubulin/FtsZ_C_sf.)
Pfam PF00091 (Tubulin)
PF03953 (Tubulin_C)