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Target Report Card

Target Name and Classification

Target ID CHEMBL4138
Preferred Name Voltage-gated L-type calcium channel alpha-1D subunit
Synonyms CACH3 | CACN4 | CACNA1D | CACNL1A2 | CCHL1A2 | Calcium channel, L type, alpha-1 polypeptide, isoform 2 | Voltage-dependent L-type calcium channel subunit alpha-1D | Voltage-gated calcium channel subunit alpha Cav1.3
Organism Homo sapiens
Species Group No
Protein Target Classification
  • ion channel > voltage-gated ion channel > voltage-gated calcium channel

Target Components

Component Description Relationship Accession
Voltage-dependent L-type calcium channel subunit alpha-1D SINGLE PROTEIN Q01668

Target Relations

ChEMBL ID Pref Name Target Type
CHEMBL2095229 Voltage-gated L-type calcium channel PROTEIN FAMILY
CHEMBL2363032 Voltage-gated calcium channel PROTEIN COMPLEX GROUP

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000157388
Ensembl ENSG00000157388
GO Cellular Component GO:0005886 (plasma membrane)
GO:0005891 (voltage-gated calcium channel complex)
GO:0016020 (membrane)
GO:0016021 (integral component of membrane)
GO:0030018 (Z disc)
GO:1990454 (L-type voltage-gated calcium channel complex)
GO Molecular Function GO:0005216 (ion channel activity)
GO:0005244 (voltage-gated ion channel activity)
GO:0005245 (voltage-gated calcium channel activity)
GO:0005262 (calcium channel activity)
GO:0008331 (high voltage-gated calcium channel activity)
GO:0030506 (ankyrin binding)
GO:0046872 (metal ion binding)
GO:0051393 (alpha-actinin binding)
GO:0086007 (voltage-gated calcium channel activity involved in cardiac muscle cell action potential)
GO:0086059 (voltage-gated calcium channel activity involved SA node cell action potential)
GO Biological Process GO:0006811 (ion transport)
GO:0006816 (calcium ion transport)
GO:0007188 (adenylate cyclase-modulating G-protein coupled receptor signaling pathway)
GO:0007605 (sensory perception of sound)
GO:0034765 (regulation of ion transmembrane transport)
GO:0050796 (regulation of insulin secretion)
GO:0051928 (positive regulation of calcium ion transport)
GO:0055085 (transmembrane transport)
GO:0060372 (regulation of atrial cardiac muscle cell membrane repolarization)
GO:0061337 (cardiac conduction)
GO:0070509 (calcium ion import)
GO:0070588 (calcium ion transmembrane transport)
GO:0086002 (cardiac muscle cell action potential involved in contraction)
GO:0086012 (membrane depolarization during cardiac muscle cell action potential)
GO:0086046 (membrane depolarization during SA node cell action potential)
GO:0086091 (regulation of heart rate by cardiac conduction)
GO:1901016 (regulation of potassium ion transmembrane transporter activity)
GO:1901379 (regulation of potassium ion transmembrane transport)
Wikipedia Cav1.3

Target Cross References - Protein

canSAR Q01668
CGD Sinoatrial node dysfunction and deafness
Human Protein Atlas ENSG00000157388
IntAct Q01668
Guide to Pharmacology 530
Open Targets ENSG00000157388
PharmGKB PA84
Pharos Q01668 (Tclin)
Reactome R-HSA-400042 (Adrenaline,noradrenaline inhibits insulin secretion.)
R-HSA-419037 (NCAM1 interactions.)
R-HSA-422356 (Regulation of insulin secretion.)
R-HSA-5576892 (Phase 0 - rapid depolarisation.)
R-HSA-5576893 (Phase 2 - plateau phase.)
UniProt B0FYA3 Q01668 Q13916 Q13931 Q71UT1 Q9UDC3

Target Cross References - Domain

InterPro IPR002077 (VDCCAlpha1.)
IPR005446 (VDCC_L_a1su.)
IPR005452 (LVDCC_a1dsu.)
IPR005821 (Ion_trans_dom.)
IPR014873 (VDCC_a1su_IQ.)
IPR027359 (Volt_channel_dom_sf.)
IPR031649 (GPHH_dom.)
IPR031688 (CAC1F_C.)
Pfam PF00520 (Ion_trans)
PF08763 (Ca_chan_IQ)
PF16885 (CAC1F_C)
PF16905 (GPHH)

Target Cross References - Structure