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Target Report Card

Target Name and Classification

Target ID CHEMBL4132
Preferred Name Voltage-gated L-type calcium channel alpha-1D subunit
Synonyms Cach3 | Cacn4 | Cacna1d | Cacnl1a2 | Calcium channel, L type, alpha-1 polypeptide, isoform 2 | Cchl1a2 | RBD | Rat brain class D | Voltage-dependent L-type calcium channel subunit alpha-1D | Voltage-gated calcium channel subunit alpha Cav1.3
Organism Rattus norvegicus
Species Group No
Protein Target Classification
  • ion channel > voltage-gated ion channel > voltage-gated calcium channel

Target Components

Component Description Relationship Accession
Voltage-dependent L-type calcium channel subunit alpha-1D SINGLE PROTEIN P27732

Target Relations

ChEMBL ID Pref Name Target Type
CHEMBL2095177 Voltage-gated L-type calcium channel PROTEIN FAMILY
CHEMBL3137269 Cav1.3/Cav beta3 complex PROTEIN COMPLEX
CHEMBL3137270 Cav1.3/Cav beta3/Cav alpha2delta complex PROTEIN COMPLEX

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

GO Cellular Component GO:0005634 (nucleus)
GO:0005886 (plasma membrane)
GO:0005891 (voltage-gated calcium channel complex)
GO:0016020 (membrane)
GO:0016021 (integral component of membrane)
GO:0016324 (apical plasma membrane)
GO:0030425 (dendrite)
GO:0032590 (dendrite membrane)
GO:0042383 (sarcolemma)
GO:0043025 (neuronal cell body)
GO Molecular Function GO:0005216 (ion channel activity)
GO:0005244 (voltage-gated ion channel activity)
GO:0005245 (voltage-gated calcium channel activity)
GO:0005262 (calcium channel activity)
GO:0005515 (protein binding)
GO:0008331 (high voltage-gated calcium channel activity)
GO:0030165 (PDZ domain binding)
GO:0030506 (ankyrin binding)
GO:0046872 (metal ion binding)
GO:0086007 (voltage-gated calcium channel activity involved in cardiac muscle cell action potential)
GO Biological Process GO:0006811 (ion transport)
GO:0006816 (calcium ion transport)
GO:0007507 (heart development)
GO:0007568 (aging)
GO:0007613 (memory)
GO:0019722 (calcium-mediated signaling)
GO:0032793 (positive regulation of CREB transcription factor activity)
GO:0034765 (regulation of ion transmembrane transport)
GO:0035774 (positive regulation of insulin secretion involved in cellular response to glucose stimulus)
GO:0051924 (regulation of calcium ion transport)
GO:0055085 (transmembrane transport)
GO:0070509 (calcium ion import)
GO:0070588 (calcium ion transmembrane transport)
GO:0070838 (divalent metal ion transport)
GO:0086010 (membrane depolarization during action potential)
GO:0086012 (membrane depolarization during cardiac muscle cell action potential)

Target Cross References - Protein

canSAR P27732
IntAct P27732
Guide to Pharmacology 530
UniProt O09022 O09023 O09024 P27732 Q01542 Q62691 Q62815 Q63491 Q63492

Target Cross References - Domain

InterPro IPR002077 (VDCCAlpha1.)
IPR005446 (VDCC_L_a1su.)
IPR005452 (LVDCC_a1dsu.)
IPR005821 (Ion_trans_dom.)
IPR014873 (VDCC_a1su_IQ.)
IPR027359 (Volt_channel_dom_sf.)
IPR031649 (GPHH_dom.)
IPR031688 (CAC1F_C.)
Pfam PF00520 (Ion_trans)
PF08763 (Ca_chan_IQ)
PF16885 (CAC1F_C)
PF16905 (GPHH)