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ChEMBL

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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL4131
Target Type SINGLE PROTEIN
Preferred Name Sodium/potassium-transporting ATPase alpha-1 chain
Synonyms ATP1A1 | Na(+)/K(+) ATPase alpha-1 subunit | Sodium pump subunit alpha-1 | Sodium/potassium-transporting ATPase subunit alpha-1
Organism Sus scrofa
Species Group No
Protein Target Classification
  • transporter > primary active transporter > p-type atpase > sodium potassium atpase
  • enzyme > hydrolase

Target Components

Component Description Relationship Accession
Sodium/potassium-transporting ATPase subunit alpha-1 SINGLE PROTEIN P05024

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

GO Cellular Component GO:0005886 (plasma membrane)
GO:0005890 (sodium:potassium-exchanging ATPase complex)
GO:0016020 (membrane)
GO:0016021 (integral component of membrane)
GO:0042383 (sarcolemma)
GO:0043231 (intracellular membrane-bounded organelle)
GO Molecular Function GO:0000166 (nucleotide binding)
GO:0005391 (sodium:potassium-exchanging ATPase activity)
GO:0005515 (protein binding)
GO:0005524 (ATP binding)
GO:0016787 (hydrolase activity)
GO:0030955 (potassium ion binding)
GO:0031402 (sodium ion binding)
GO:0046872 (metal ion binding)
GO:0051117 (ATPase binding)
GO Biological Process GO:0002028 (regulation of sodium ion transport)
GO:0006810 (transport)
GO:0006811 (ion transport)
GO:0006813 (potassium ion transport)
GO:0006814 (sodium ion transport)
GO:0006883 (cellular sodium ion homeostasis)
GO:0010107 (potassium ion import)
GO:0010248 (establishment or maintenance of transmembrane electrochemical gradient)
GO:0015991 (ATP hydrolysis coupled proton transport)
GO:0030007 (cellular potassium ion homeostasis)
GO:0036376 (sodium ion export from cell)
GO:0086009 (membrane repolarization)
GO:0090662 (ATP hydrolysis coupled transmembrane transport)
GO:1990573 (potassium ion import across plasma membrane)

Target Cross References - Protein

canSAR P05024
IntAct P05024
UniProt P05024 P18874

Target Cross References - Domain

InterPro IPR001757 (P_typ_ATPase.)
IPR004014 (ATPase_P-typ_cation-transptr_N.)
IPR005775 (P-type_ATPase_IIC.)
IPR006068 (ATPase_P-typ_cation-transptr_C.)
IPR008250 (ATPase_P-typ_transduc_dom_A.)
IPR018303 (ATPase_P-typ_P_site.)
IPR023214 (HAD-like_dom.)
IPR023298 (ATPase_P-typ_TM_dom.)
IPR023299 (ATPase_P-typ_cyto_domN.)
Pfam PF00122 (E1-E2_ATPase)
PF00689 (Cation_ATPase_C)
PF00690 (Cation_ATPase_N)

Target Cross References - Structure

PDBe 3B8E 3KDP 3N23 3WGU 3WGV 4HQJ 4HYT 4RES 4RET
CREDO 3B8E 3KDP 3N23 3WGU 3WGV 4HQJ 4HYT 4RES 4RET
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