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ChEMBL

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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL4124
Target Type SINGLE PROTEIN
Preferred Name Histamine H3 receptor
Synonyms H3R | HH3R | Histamine H3 receptor | Hrh3
Organism Rattus norvegicus
Species Group No
Protein Target Classification
  • membrane receptor > family a g protein-coupled receptor > small molecule receptor (family a gpcr) > monoamine receptor > histamine receptor

Target Components

Component Description Relationship Accession
Histamine H3 receptor SINGLE PROTEIN Q9QYN8

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

GO Cellular Component GO:0005886 (plasma membrane)
GO:0016020 (membrane)
GO:0016021 (integral component of membrane)
GO:0043005 (neuron projection)
GO:0043209 (myelin sheath)
GO Molecular Function GO:0004871 (signal transducer activity)
GO:0004930 (G-protein coupled receptor activity)
GO:0004969 (histamine receptor activity)
GO:0008144 (drug binding)
GO Biological Process GO:0001505 (regulation of neurotransmitter levels)
GO:0007165 (signal transduction)
GO:0007186 (G-protein coupled receptor signaling pathway)
GO:0007194 (negative regulation of adenylate cyclase activity)
GO:0007204 (positive regulation of cytosolic calcium ion concentration)
GO:0007420 (brain development)
GO:0007612 (learning)
GO:0007613 (memory)
GO:0014050 (negative regulation of glutamate secretion)
GO:0014053 (negative regulation of gamma-aminobutyric acid secretion)
GO:0014061 (regulation of norepinephrine secretion)
GO:0014063 (negative regulation of serotonin secretion)
GO:0014070 (response to organic cyclic compound)
GO:0042755 (eating behavior)
GO:0042756 (drinking behavior)
GO:0045776 (negative regulation of blood pressure)
GO:0050679 (positive regulation of epithelial cell proliferation)
GO:0050890 (cognition)

Target Cross References - Protein

canSAR Q9QYN8
Guide to Pharmacology 264
MICAD NBK23610 (Histamine H3 receptor)
NBK23693 (Histamine H3 receptor)
UniProt Q9QYN6 Q9QYN7 Q9QYN8 Q9QYN9

Target Cross References - Domain

InterPro IPR000276 (GPCR_Rhodpsn.)
IPR003980 (Histamine_H3_rcpt.)
IPR017452 (GPCR_Rhodpsn_7TM.)
Pfam PF00001 (7tm_1)
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