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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL4116
Target Type SINGLE PROTEIN
Preferred Name Alcohol dehydrogenase class III
Synonyms ADH5 | ADHX | Alcohol dehydrogenase 5 | Alcohol dehydrogenase class chi chain | Alcohol dehydrogenase class-3 | Alcohol dehydrogenase class-III | FALDH | FDH | FDH | GSH-FDH | Glutathione-dependent formaldehyde dehydrogenase | S-(hydroxymethyl)glutathione dehydrogenase
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme

Target Components

Component Description Relationship Accession
Alcohol dehydrogenase class-3 SINGLE PROTEIN P11766

Target Relations

ChEMBL ID Pref Name Target Type
CHEMBL2096668 Alcohol dehydrogenase PROTEIN FAMILY

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000197894
Ensembl ENSG00000197894
GO Cellular Component GO:0005737 (cytoplasm)
GO:0005739 (mitochondrion)
GO:0005829 (cytosol)
GO:0070062 (extracellular exosome)
GO Molecular Function GO:0004022 (alcohol dehydrogenase (NAD) activity)
GO:0005504 (fatty acid binding)
GO:0008270 (zinc ion binding)
GO:0009055 (electron carrier activity)
GO:0016491 (oxidoreductase activity)
GO:0018467 (formaldehyde dehydrogenase activity)
GO:0042803 (protein homodimerization activity)
GO:0046872 (metal ion binding)
GO:0051903 (S-(hydroxymethyl)glutathione dehydrogenase activity)
GO Biological Process GO:0001523 (retinoid metabolic process)
GO:0003016 (respiratory system process)
GO:0006069 (ethanol oxidation)
GO:0018119 (peptidyl-cysteine S-nitrosylation)
GO:0032496 (response to lipopolysaccharide)
GO:0045777 (positive regulation of blood pressure)
GO:0046294 (formaldehyde catabolic process)
GO:0051409 (response to nitrosative stress)
GO:0051775 (response to redox state)
GO:0055114 (oxidation-reduction process)
Wikipedia ADH5

Target Cross References - Protein

canSAR P11766
Human Protein Atlas ENSG00000197894
IntAct P11766
Open Targets ENSG00000197894
PharmGKB PA24574
Reactome R-HSA-71384 (Ethanol oxidation.)
UniProt P11766 Q6FHR2

Target Cross References - Domain

InterPro IPR002328 (ADH_Zn_CS.)
IPR011032 (GroES-like.)
IPR013149 (ADH_C.)
IPR013154 (ADH_N.)
IPR014183 (ADH_3.)
IPR016040 (NAD(P)-bd_dom.)
Pfam PF00107 (ADH_zinc_N)
PF08240 (ADH_N)

Target Cross References - Structure

PDBe 1M6H 1M6W 1MA0 1MC5 1MP0 1TEH 2FZE 2FZW 3QJ5
CREDO 1M6H 1M6W 1MA0 1MC5 1MP0 1TEH 2FZE 2FZW 3QJ5
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