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Target Report Card

Target Name and Classification

Target ID CHEMBL4112
Preferred Name Retina-specific amine oxidase, copper containing
Synonyms AOC2 | Amine oxidase [copper-containing] | RAO | Retina-specific copper amine oxidase | SSAO | Semicarbazide-sensitive amine oxidase
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme

Target Components

Component Description Relationship Accession
Retina-specific copper amine oxidase SINGLE PROTEIN O75106

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000131480
Ensembl ENSG00000131480
GO Cellular Component GO:0005737 (cytoplasm)
GO:0005886 (plasma membrane)
GO:0016020 (membrane)
GO Molecular Function GO:0005507 (copper ion binding)
GO:0008131 (primary amine oxidase activity)
GO:0009055 (electron carrier activity)
GO:0016491 (oxidoreductase activity)
GO:0046872 (metal ion binding)
GO:0048038 (quinone binding)
GO:0052593 (tryptamine:oxygen oxidoreductase (deaminating) activity)
GO:0052594 (aminoacetone:oxygen oxidoreductase(deaminating) activity)
GO:0052595 (aliphatic-amine oxidase activity)
GO:0052596 (phenethylamine:oxygen oxidoreductase (deaminating) activity)
GO Biological Process GO:0006584 (catecholamine metabolic process)
GO:0006805 (xenobiotic metabolic process)
GO:0007601 (visual perception)
GO:0009308 (amine metabolic process)
GO:0055114 (oxidation-reduction process)

Target Cross References - Protein

canSAR O75106
Human Protein Atlas ENSG00000131480
Open Targets ENSG00000131480
PharmGKB PA24839
Reactome R-HSA-211945 (Phase 1 - Functionalization of compounds.)
UniProt A5PKW2 O00120 O75105 O75106 Q4TTW5 Q9UNY0

Target Cross References - Domain

InterPro IPR000269 (Cu_amine_oxidase.)
IPR015798 (Cu_amine_oxidase_C.)
IPR015800 (Cu_amine_oxidase_N2.)
IPR015802 (Cu_amine_oxidase_N3.)
IPR016182 (Cu_amine_oxidase_N-reg.)
IPR032952 (AOC2.)
Pfam PF01179 (Cu_amine_oxid)
PF02727 (Cu_amine_oxidN2)
PF02728 (Cu_amine_oxidN3)