ChEMBL logo


ChEMBL Statistics
  Loading Statistics...

Target Report Card

Target Name and Classification

Target ID CHEMBL4109
Preferred Name Glutamate [NMDA] receptor subunit epsilon 3
Synonyms GRIN2C | GluN2C | Glutamate [NMDA] receptor subunit epsilon-3 | Glutamate receptor ionotropic, NMDA 2C | N-methyl D-aspartate receptor subtype 2C | NMDAR2C | NMDAR2C | NR2C
Organism Homo sapiens
Species Group No
Protein Target Classification
  • ion channel > ligand-gated ion channel > ionotropic glutamate receptor > nmda receptor

Target Components

Component Description Relationship Accession
Glutamate receptor ionotropic, NMDA 2C SINGLE PROTEIN Q14957

Target Relations

ChEMBL ID Pref Name Target Type
CHEMBL2094124 Glutamate [NMDA] receptor PROTEIN COMPLEX GROUP
CHEMBL3038504 Ionotropic glutamate receptor NMDA 1/2C PROTEIN COMPLEX

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000161509
Ensembl ENSG00000161509
GO Cellular Component GO:0005622 (intracellular)
GO:0005886 (plasma membrane)
GO:0005887 (integral component of plasma membrane)
GO:0016020 (membrane)
GO:0016021 (integral component of membrane)
GO:0017146 (NMDA selective glutamate receptor complex)
GO:0030054 (cell junction)
GO:0045202 (synapse)
GO:0045211 (postsynaptic membrane)
GO Molecular Function GO:0004970 (ionotropic glutamate receptor activity)
GO:0004972 (NMDA glutamate receptor activity)
GO:0005088 (Ras guanyl-nucleotide exchange factor activity)
GO:0005216 (ion channel activity)
GO:0005234 (extracellular-glutamate-gated ion channel activity)
GO:0005261 (cation channel activity)
GO:0005515 (protein binding)
GO:0022849 (glutamate-gated calcium ion channel activity)
GO:0038023 (signaling receptor activity)
GO Biological Process GO:0000165 (MAPK cascade)
GO:0006811 (ion transport)
GO:0007215 (glutamate receptor signaling pathway)
GO:0007420 (brain development)
GO:0009611 (response to wounding)
GO:0019722 (calcium-mediated signaling)
GO:0033058 (directional locomotion)
GO:0035235 (ionotropic glutamate receptor signaling pathway)
GO:0042177 (negative regulation of protein catabolic process)
GO:0042391 (regulation of membrane potential)
GO:0048167 (regulation of synaptic plasticity)
GO:0050885 (neuromuscular process controlling balance)
GO:0060079 (excitatory postsynaptic potential)
GO:0097553 (calcium ion transmembrane import into cytosol)
GO:0098976 (excitatory chemical synaptic transmission)
GO:1903539 (protein localization to postsynaptic membrane)
Wikipedia GRIN2C

Target Cross References - Protein

Human Protein Atlas ENSG00000161509
IntAct Q14957
Guide to Pharmacology 458
Open Targets ENSG00000161509
PharmGKB PA28981
Pharos Q14957 (Tclin)
Reactome R-HSA-438066 (Unblocking of NMDA receptor, glutamate binding and activation.)
R-HSA-442729 (CREB phosphorylation through the activation of CaMKII.)
R-HSA-442982 (Ras activation upon Ca2+ influx through NMDA receptor.)
R-HSA-5673001 (RAF/MAP kinase cascade.)
R-HSA-6794361 (Neurexins and neuroligins.)
R-HSA-8849932 (Synaptic adhesion-like molecules.)
UniProt B2RTT1 Q14957

Target Cross References - Domain

InterPro IPR001320 (Iontro_rcpt.)
IPR001508 (Iono_rcpt_met.)
IPR001828 (ANF_lig-bd_rcpt.)
IPR018884 (NMDAR2_C.)
IPR019594 (Glu/Gly-bd.)
IPR028082 (Peripla_BP_I.)
Pfam PF00060 (Lig_chan)
PF01094 (ANF_receptor)
PF10565 (NMDAR2_C)
PF10613 (Lig_chan-Glu_bd)