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Target Report Card

Target Name and Classification

Target ID CHEMBL4108
Preferred Name Voltage-gated L-type calcium channel alpha-1S subunit
Synonyms Cach1 | Cacn1 | Cacna1s | Cacnl1a3 | Calcium channel, L type, alpha-1 polypeptide, isoform 3, skeletal muscle | Cchl1a3 | ROB1 | Voltage-dependent L-type calcium channel subunit alpha-1S | Voltage-gated calcium channel subunit alpha Cav1.1
Organism Rattus norvegicus
Species Group No
Protein Target Classification
  • ion channel > voltage-gated ion channel > voltage-gated calcium channel

Target Components

Component Description Relationship Accession
Voltage-dependent L-type calcium channel subunit alpha-1S SINGLE PROTEIN Q02485

Target Relations

ChEMBL ID Pref Name Target Type
CHEMBL2095177 Voltage-gated L-type calcium channel PROTEIN FAMILY

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

GO Cellular Component GO:0005886 (plasma membrane)
GO:0005891 (voltage-gated calcium channel complex)
GO:0016020 (membrane)
GO:0016021 (integral component of membrane)
GO:0030315 (T-tubule)
GO:0042383 (sarcolemma)
GO:1990454 (L-type voltage-gated calcium channel complex)
GO Molecular Function GO:0005216 (ion channel activity)
GO:0005244 (voltage-gated ion channel activity)
GO:0005245 (voltage-gated calcium channel activity)
GO:0005262 (calcium channel activity)
GO:0005516 (calmodulin binding)
GO:0008331 (high voltage-gated calcium channel activity)
GO:0046872 (metal ion binding)
GO Biological Process GO:0001503 (ossification)
GO:0006811 (ion transport)
GO:0006816 (calcium ion transport)
GO:0034765 (regulation of ion transmembrane transport)
GO:0055085 (transmembrane transport)
GO:0070588 (calcium ion transmembrane transport)
GO:0071313 (cellular response to caffeine)
GO:0086010 (membrane depolarization during action potential)

Target Cross References - Protein

canSAR Q02485
Guide to Pharmacology 528
UniProt B3XZL8 P70484 Q01553 Q02485 Q62817

Target Cross References - Domain

InterPro IPR002077 (VDCCAlpha1.)
IPR005446 (VDCC_L_a1su.)
IPR005450 (VDCC_L_a1ssu.)
IPR005821 (Ion_trans_dom.)
IPR014873 (VDCC_a1su_IQ.)
IPR027359 (Volt_channel_dom_sf.)
IPR031649 (GPHH_dom.)
Pfam PF00520 (Ion_trans)
PF08763 (Ca_chan_IQ)
PF16905 (GPHH)