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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL4102
Target Type SINGLE PROTEIN
Preferred Name Cyclooxygenase-2
Synonyms COX-2 | COX2 | Cyclooxygenase-2 | PGH synthase 2 | PGHS-2 | PHS II | PTGS2 | Prostaglandin G/H synthase 2 | Prostaglandin H2 synthase 2 | Prostaglandin-endoperoxide synthase 2
Organism Ovis aries
Species Group No
Protein Target Classification
  • enzyme > oxidoreductase

Target Components

Component Description Relationship Accession
Prostaglandin G/H synthase 2 SINGLE PROTEIN P79208

Target Relations

ChEMBL ID Pref Name Target Type
CHEMBL2111358 Prostaglandin G/H synthase (cyclooxygenase) PROTEIN FAMILY

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

GO Cellular Component GO:0005737 (cytoplasm)
GO:0005783 (endoplasmic reticulum)
GO:0005789 (endoplasmic reticulum membrane)
GO:0016020 (membrane)
GO:0031090 (organelle membrane)
GO:0043231 (intracellular membrane-bounded organelle)
GO Molecular Function GO:0004601 (peroxidase activity)
GO:0004666 (prostaglandin-endoperoxide synthase activity)
GO:0016491 (oxidoreductase activity)
GO:0020037 (heme binding)
GO:0046872 (metal ion binding)
GO:0051213 (dioxygenase activity)
GO Biological Process GO:0001516 (prostaglandin biosynthetic process)
GO:0006629 (lipid metabolic process)
GO:0006631 (fatty acid metabolic process)
GO:0006633 (fatty acid biosynthetic process)
GO:0006693 (prostaglandin metabolic process)
GO:0006954 (inflammatory response)
GO:0006979 (response to oxidative stress)
GO:0008217 (regulation of blood pressure)
GO:0019371 (cyclooxygenase pathway)
GO:0055114 (oxidation-reduction process)
GO:0098869 (cellular oxidant detoxification)

Target Cross References - Protein

canSAR P79208
UniProt P79208

Target Cross References - Domain

InterPro IPR000742 (EGF-like_dom.)
IPR010255 (Haem_peroxidase.)
IPR019791 (Haem_peroxidase_animal.)
IPR029576 (COX-2.)
IPR037120 (Haem_peroxidase_sf.)
Pfam PF00008 (EGF)
PF03098 (An_peroxidase)
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