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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL4079
Target Type SINGLE PROTEIN
Preferred Name G-protein coupled receptor kinase 2
Synonyms ADRBK1 | BARK | BARK1 | Beta-ARK-1 | Beta-adrenergic receptor kinase 1 | G-protein coupled receptor kinase 2 | GRK2
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme > kinase > protein kinase > agc protein kinase group > agc protein kinase grk family > agc protein kinase bark subfamily

Target Components

Component Description Relationship Accession
Beta-adrenergic receptor kinase 1 SINGLE PROTEIN P25098

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000173020
Ensembl ENSG00000173020
GO Cellular Component GO:0005737 (cytoplasm)
GO:0005829 (cytosol)
GO:0005886 (plasma membrane)
GO:0016020 (membrane)
GO:0072372 (primary cilium)
GO Molecular Function GO:0000166 (nucleotide binding)
GO:0004672 (protein kinase activity)
GO:0004674 (protein serine/threonine kinase activity)
GO:0004703 (G-protein coupled receptor kinase activity)
GO:0005515 (protein binding)
GO:0005524 (ATP binding)
GO:0016301 (kinase activity)
GO:0016740 (transferase activity)
GO:0031694 (alpha-2A adrenergic receptor binding)
GO:0031755 (Edg-2 lysophosphatidic acid receptor binding)
GO:0047696 (beta-adrenergic receptor kinase activity)
GO Biological Process GO:0002026 (regulation of the force of heart contraction)
GO:0002029 (desensitization of G-protein coupled receptor protein signaling pathway)
GO:0003108 (negative regulation of the force of heart contraction by chemical signal)
GO:0006468 (protein phosphorylation)
GO:0007165 (signal transduction)
GO:0007186 (G-protein coupled receptor signaling pathway)
GO:0007213 (G-protein coupled acetylcholine receptor signaling pathway)
GO:0007217 (tachykinin receptor signaling pathway)
GO:0007507 (heart development)
GO:0016310 (phosphorylation)
GO:0018105 (peptidyl-serine phosphorylation)
GO:0018107 (peptidyl-threonine phosphorylation)
GO:0019079 (viral genome replication)
GO:0031623 (receptor internalization)
GO:0033605 (positive regulation of catecholamine secretion)
GO:0045988 (negative regulation of striated muscle contraction)
GO:0046718 (viral entry into host cell)
GO:0060048 (cardiac muscle contraction)
Wikipedia Beta_adrenergic_receptor_kinase

Target Cross References - Protein

canSAR P25098
Human Protein Atlas ENSG00000173020
IntAct P25098
Guide to Pharmacology 1466
Open Targets ENSG00000173020
PharmGKB PA40
Pharos P25098 (Tbio)
Reactome R-HSA-111933 (Calmodulin induced events.)
R-HSA-416476 (G alpha (q) signalling events.)
R-HSA-418555 (G alpha (s) signalling events.)
R-HSA-5635838 (Activation of SMO.)
R-HSA-8856825 (Cargo recognition for clathrin-mediated endocytosis.)
UniProt B0ZBE1 P25098 Q13837 Q6GTT3

Target Cross References - Domain

InterPro IPR000239 (GPCR_kinase.)
IPR000719 (Prot_kinase_dom.)
IPR000961 (AGC-kinase_C.)
IPR001849 (PH_domain.)
IPR008271 (Ser/Thr_kinase_AS.)
IPR011009 (Kinase-like_dom.)
IPR011993 (PH_dom-like.)
IPR016137 (RGS.)
IPR017441 (Protein_kinase_ATP_BS.)
Pfam PF00069 (Pkinase)
PF00169 (PH)
PF00615 (RGS)

Target Cross References - Structure

PDBe 3CIK 3KRW 3KRX 3V5W 4MK0 4PNK 5HE1
CREDO 3CIK 3KRW 3KRX 3V5W 4MK0 4PNK 5HE1
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