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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL4079
Target Type SINGLE PROTEIN
Preferred Name G-protein coupled receptor kinase 2
Synonyms ADRBK1 | BARK | BARK1 | Beta-ARK-1 | Beta-adrenergic receptor kinase 1 | G-protein coupled receptor kinase 2 | GRK2
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme > kinase > protein kinase > agc protein kinase group > agc protein kinase grk family > agc protein kinase bark subfamily

Target Components

Component Description Relationship Accession
Beta-adrenergic receptor kinase 1 SINGLE PROTEIN P25098

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000173020
Ensembl ENSG00000173020
GO Cellular Component GO:0005737 (cytoplasm)
GO:0005829 (cytosol)
GO:0005886 (plasma membrane)
GO:0005929 (cilium)
GO:0016020 (membrane)
GO Molecular Function GO:0000166 (nucleotide binding)
GO:0004672 (protein kinase activity)
GO:0004674 (protein serine/threonine kinase activity)
GO:0004703 (G-protein coupled receptor kinase activity)
GO:0005515 (protein binding)
GO:0005524 (ATP binding)
GO:0016301 (kinase activity)
GO:0016740 (transferase activity)
GO:0031694 (alpha-2A adrenergic receptor binding)
GO:0031755 (Edg-2 lysophosphatidic acid receptor binding)
GO:0047696 (beta-adrenergic receptor kinase activity)
GO Biological Process GO:0002026 (regulation of the force of heart contraction)
GO:0002029 (desensitization of G-protein coupled receptor protein signaling pathway)
GO:0003108 (negative regulation of the force of heart contraction by chemical signal)
GO:0006468 (protein phosphorylation)
GO:0007165 (signal transduction)
GO:0007186 (G-protein coupled receptor signaling pathway)
GO:0007213 (G-protein coupled acetylcholine receptor signaling pathway)
GO:0007217 (tachykinin receptor signaling pathway)
GO:0007507 (heart development)
GO:0016310 (phosphorylation)
GO:0018105 (peptidyl-serine phosphorylation)
GO:0018107 (peptidyl-threonine phosphorylation)
GO:0019079 (viral genome replication)
GO:0031623 (receptor internalization)
GO:0033605 (positive regulation of catecholamine secretion)
GO:0045988 (negative regulation of striated muscle contraction)
GO:0046718 (viral entry into host cell)
GO:0060048 (cardiac muscle contraction)
Wikipedia Beta_adrenergic_receptor_kinase

Target Cross References - Protein

canSAR P25098
Human Protein Atlas ENSG00000173020
IntAct P25098
Guide to Pharmacology 1466
Open Targets ENSG00000173020
PharmGKB PA40
Pharos P25098 (Tbio)
Reactome R-HSA-111933 (Calmodulin induced events.)
R-HSA-416476 (G alpha (q) signalling events.)
R-HSA-418555 (G alpha (s) signalling events.)
R-HSA-5635838 (Activation of SMO.)
R-HSA-8856825 (Cargo recognition for clathrin-mediated endocytosis.)
UniProt B0ZBE1 P25098 Q13837 Q6GTT3

Target Cross References - Domain

InterPro IPR000239 (GPCR_kinase.)
IPR000719 (Prot_kinase_dom.)
IPR000961 (AGC-kinase_C.)
IPR001849 (PH_domain.)
IPR008271 (Ser/Thr_kinase_AS.)
IPR011009 (Kinase-like_dom_sf.)
IPR011993 (PH-like_dom_sf.)
IPR016137 (RGS.)
IPR017441 (Protein_kinase_ATP_BS.)
IPR036305 (RGS_sf.)
Pfam PF00069 (Pkinase)
PF00169 (PH)
PF00615 (RGS)

Target Cross References - Structure

PDBe 3CIK 3KRW 3KRX 3V5W 4MK0 4PNK 5HE1 5UKK 5UKL 5UUU 5UVC 5WG3 5WG4 5WG5
CREDO 3CIK 3KRW 3KRX 3V5W 4MK0 4PNK 5HE1 5UKK 5UKL 5UUU 5UVC 5WG3 5WG4 5WG5
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