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Target Report Card

Target Name and Classification

Target ID CHEMBL4075
Preferred Name Alpha-2a adrenergic receptor
Synonyms Adra2a | Alpha-2A adrenergic receptor | Alpha-2A adrenoceptor | Alpha-2A adrenoreceptor | Alpha-2AAR
Organism Mus musculus
Species Group No
Protein Target Classification
  • membrane receptor > family a g protein-coupled receptor > small molecule receptor (family a gpcr) > monoamine receptor > adrenergic receptor

Target Components

Component Description Relationship Accession
Alpha-2A adrenergic receptor SINGLE PROTEIN Q01338

Target Relations

ChEMBL ID Pref Name Target Type
CHEMBL2111338 Alpha-2 adrenergic receptor PROTEIN FAMILY

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

GO Cellular Component GO:0005737 (cytoplasm)
GO:0005886 (plasma membrane)
GO:0005887 (integral component of plasma membrane)
GO:0016020 (membrane)
GO:0016021 (integral component of membrane)
GO:0043235 (receptor complex)
GO:0045202 (synapse)
GO Molecular Function GO:0004871 (signal transducer activity)
GO:0004930 (G-protein coupled receptor activity)
GO:0004935 (adrenergic receptor activity)
GO:0004938 (alpha2-adrenergic receptor activity)
GO:0005515 (protein binding)
GO:0019901 (protein kinase binding)
GO:0031696 (alpha-2C adrenergic receptor binding)
GO:0031996 (thioesterase binding)
GO:0032795 (heterotrimeric G-protein binding)
GO:0042803 (protein homodimerization activity)
GO:0046982 (protein heterodimerization activity)
GO:0051379 (epinephrine binding)
GO:0051380 (norepinephrine binding)
GO Biological Process GO:0001819 (positive regulation of cytokine production)
GO:0002526 (acute inflammatory response)
GO:0006260 (DNA replication)
GO:0006940 (regulation of smooth muscle contraction)
GO:0007165 (signal transduction)
GO:0007186 (G-protein coupled receptor signaling pathway)
GO:0007267 (cell-cell signaling)
GO:0007565 (female pregnancy)
GO:0019229 (regulation of vasoconstriction)
GO:0030168 (platelet activation)
GO:0030335 (positive regulation of cell migration)
GO:0032147 (activation of protein kinase activity)
GO:0032148 (activation of protein kinase B activity)
GO:0032870 (cellular response to hormone stimulus)
GO:0035625 (epidermal growth factor-activated receptor transactivation by G-protein coupled receptor signaling pathway)
GO:0042593 (glucose homeostasis)
GO:0042596 (fear response)
GO:0043406 (positive regulation of MAP kinase activity)
GO:0043410 (positive regulation of MAPK cascade)
GO:0045741 (positive regulation of epidermal growth factor-activated receptor activity)
GO:0045955 (negative regulation of calcium ion-dependent exocytosis)
GO:0046676 (negative regulation of insulin secretion)
GO:0050955 (thermoception)
GO:0050995 (negative regulation of lipid catabolic process)
GO:0051044 (positive regulation of membrane protein ectodomain proteolysis)
GO:0061179 (negative regulation of insulin secretion involved in cellular response to glucose stimulus)
GO:0070473 (negative regulation of uterine smooth muscle contraction)
GO:0071875 (adrenergic receptor signaling pathway)
GO:0071880 (adenylate cyclase-activating adrenergic receptor signaling pathway)
GO:0071881 (adenylate cyclase-inhibiting adrenergic receptor signaling pathway)
GO:0071882 (phospholipase C-activating adrenergic receptor signaling pathway)
GO:0090303 (positive regulation of wound healing)
GO:0097755 (positive regulation of blood vessel diameter)

Target Cross References - Protein

canSAR Q01338
IntAct Q01338
UniProt Q01338

Target Cross References - Domain

InterPro IPR000276 (GPCR_Rhodpsn.)
IPR001946 (ADRA2A_rcpt.)
IPR002233 (ADR_fam.)
IPR017452 (GPCR_Rhodpsn_7TM.)
Pfam PF00001 (7tm_1)