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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL4070
Target Type SINGLE PROTEIN
Preferred Name Casein kinase II alpha (prime)
Synonyms CK II alpha' | CK2A2 | CSNK2A2 | Casein kinase II subunit alpha'
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme > kinase > protein kinase > other protein kinase group > other protein kinase ck2 family

Target Components

Component Description Relationship Accession
Casein kinase II subunit alpha' SINGLE PROTEIN P19784

Target Relations

ChEMBL ID Pref Name Target Type
CHEMBL3883328 Casein kinase II alpha'/ beta PROTEIN COMPLEX
CHEMBL3832943 Casein kinase 2 PROTEIN FAMILY
CHEMBL2095191 Casein kinase II PROTEIN COMPLEX GROUP

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000070770
Ensembl ENSG00000070770
GO Cellular Component GO:0000785 (chromatin)
GO:0001669 (acrosomal vesicle)
GO:0005634 (nucleus)
GO:0005654 (nucleoplasm)
GO:0005737 (cytoplasm)
GO:0005829 (cytosol)
GO:0005886 (plasma membrane)
GO:0031519 (PcG protein complex)
GO Molecular Function GO:0000166 (nucleotide binding)
GO:0004672 (protein kinase activity)
GO:0004674 (protein serine/threonine kinase activity)
GO:0005515 (protein binding)
GO:0005524 (ATP binding)
GO:0016301 (kinase activity)
GO:0016740 (transferase activity)
GO:0047485 (protein N-terminus binding)
GO Biological Process GO:0006351 (transcription, DNA-templated)
GO:0006355 (regulation of transcription, DNA-templated)
GO:0006457 (protein folding)
GO:0006468 (protein phosphorylation)
GO:0006656 (phosphatidylcholine biosynthetic process)
GO:0006915 (apoptotic process)
GO:0007049 (cell cycle)
GO:0007283 (spermatogenesis)
GO:0016055 (Wnt signaling pathway)
GO:0016236 (macroautophagy)
GO:0016310 (phosphorylation)
GO:0021987 (cerebral cortex development)
GO:0051726 (regulation of cell cycle)
GO:0097421 (liver regeneration)
GO:1901796 (regulation of signal transduction by p53 class mediator)
GO:1903146 (regulation of mitophagy)
GO:1903955 (positive regulation of protein targeting to mitochondrion)
GO:1905818 (regulation of chromosome separation)
Wikipedia CSNK2A2

Target Cross References - Protein

canSAR P19784
Human Protein Atlas ENSG00000070770
IntAct P19784
Guide to Pharmacology 1550
Open Targets ENSG00000070770
PharmGKB PA26959
Pharos P19784 (Tchem)
Reactome R-HSA-1483191 (Synthesis of PC.)
R-HSA-201688 (WNT mediated activation of DVL.)
R-HSA-2514853 (Condensation of Prometaphase Chromosomes.)
R-HSA-445144 (Signal transduction by L1.)
R-HSA-6804756 (Regulation of TP53 Activity through Phosphorylation.)
R-HSA-6814122 (Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding.)
R-HSA-8934903 (Receptor Mediated Mitophagy.)
R-HSA-8939243 (RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known.)
R-HSA-8948751 (Regulation of PTEN stability and activity.)
UniProt P19784

Target Cross References - Domain

InterPro IPR000719 (Prot_kinase_dom.)
IPR008271 (Ser/Thr_kinase_AS.)
IPR011009 (Kinase-like_dom_sf.)
IPR017441 (Protein_kinase_ATP_BS.)
Pfam PF00069 (Pkinase)

Target Cross References - Structure

PDBe 3E3B 3OFM 3U87 5M4U 5M56 5OOI
CREDO 3E3B 3OFM 3U87 5M4U 5M56 5OOI
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