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Target Report Card

Target Name and Classification

Target ID CHEMBL4045
Preferred Name AMP-activated protein kinase, alpha-1 subunit
Synonyms 5'-AMP-activated protein kinase catalytic subunit alpha-1 | ACACA kinase | AMPK subunit alpha-1 | AMPK1 | Acetyl-CoA carboxylase kinase | HMGCR kinase | Hydroxymethylglutaryl-CoA reductase kinase | PRKAA1 | Tau-protein kinase PRKAA1
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme > kinase > protein kinase > camk protein kinase group > camk protein kinase camk1 family > camk protein kinase ampk subfamily

Target Components

Component Description Relationship Accession
5'-AMP-activated protein kinase catalytic subunit alpha-1 SINGLE PROTEIN Q13131

Target Relations

ChEMBL ID Pref Name Target Type
CHEMBL3038451 AMPK alpha1/beta1/gamma2 PROTEIN COMPLEX
CHEMBL2111345 AMP-activated protein kinase (AMPK) alpha-1/beta-1/gamma-1 PROTEIN COMPLEX
CHEMBL3038453 AMPK alpha1/beta2/gamma1 PROTEIN COMPLEX
CHEMBL3038452 AMPK alpha1/beta1/gamma3 PROTEIN COMPLEX
CHEMBL3038454 AMPK alpha1/alpha2 PROTEIN COMPLEX
CHEMBL2096907 AMP-activated protein kinase, AMPK PROTEIN COMPLEX GROUP

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000132356
Ensembl ENSG00000132356
GO Cellular Component GO:0005622 (intracellular)
GO:0005634 (nucleus)
GO:0005654 (nucleoplasm)
GO:0005737 (cytoplasm)
GO:0005829 (cytosol)
GO:0016324 (apical plasma membrane)
GO:0016607 (nuclear speck)
GO:0030424 (axon)
GO:0030425 (dendrite)
GO:0031588 (nucleotide-activated protein kinase complex)
GO:0032991 (macromolecular complex)
GO:0043025 (neuronal cell body)
GO Molecular Function GO:0000166 (nucleotide binding)
GO:0003682 (chromatin binding)
GO:0004672 (protein kinase activity)
GO:0004674 (protein serine/threonine kinase activity)
GO:0004679 (AMP-activated protein kinase activity)
GO:0004691 (cAMP-dependent protein kinase activity)
GO:0005515 (protein binding)
GO:0005524 (ATP binding)
GO:0008022 (protein C-terminus binding)
GO:0016301 (kinase activity)
GO:0016740 (transferase activity)
GO:0035174 (histone serine kinase activity)
GO:0046872 (metal ion binding)
GO:0047322 ([hydroxymethylglutaryl-CoA reductase (NADPH)] kinase activity)
GO:0050321 (tau-protein kinase activity)
GO:0050405 ([acetyl-CoA carboxylase] kinase activity)
GO Biological Process GO:0000187 (activation of MAPK activity)
GO:0001666 (response to hypoxia)
GO:0006006 (glucose metabolic process)
GO:0006325 (chromatin organization)
GO:0006351 (transcription, DNA-templated)
GO:0006355 (regulation of transcription, DNA-templated)
GO:0006468 (protein phosphorylation)
GO:0006629 (lipid metabolic process)
GO:0006631 (fatty acid metabolic process)
GO:0006633 (fatty acid biosynthetic process)
GO:0006694 (steroid biosynthetic process)
GO:0006695 (cholesterol biosynthetic process)
GO:0006914 (autophagy)
GO:0007050 (cell cycle arrest)
GO:0007165 (signal transduction)
GO:0008202 (steroid metabolic process)
GO:0008203 (cholesterol metabolic process)
GO:0008284 (positive regulation of cell proliferation)
GO:0008610 (lipid biosynthetic process)
GO:0009411 (response to UV)
GO:0009631 (cold acclimation)
GO:0010332 (response to gamma radiation)
GO:0010508 (positive regulation of autophagy)
GO:0010628 (positive regulation of gene expression)
GO:0010629 (negative regulation of gene expression)
GO:0014823 (response to activity)
GO:0016055 (Wnt signaling pathway)
GO:0016126 (sterol biosynthetic process)
GO:0016236 (macroautophagy)
GO:0016241 (regulation of macroautophagy)
GO:0016310 (phosphorylation)
GO:0019395 (fatty acid oxidation)
GO:0031000 (response to caffeine)
GO:0031669 (cellular response to nutrient levels)
GO:0032007 (negative regulation of TOR signaling)
GO:0033135 (regulation of peptidyl-serine phosphorylation)
GO:0034599 (cellular response to oxidative stress)
GO:0035404 (histone-serine phosphorylation)
GO:0042149 (cellular response to glucose starvation)
GO:0042542 (response to hydrogen peroxide)
GO:0042593 (glucose homeostasis)
GO:0042752 (regulation of circadian rhythm)
GO:0043066 (negative regulation of apoptotic process)
GO:0045542 (positive regulation of cholesterol biosynthetic process)
GO:0045821 (positive regulation of glycolytic process)
GO:0046318 (negative regulation of glucosylceramide biosynthetic process)
GO:0048511 (rhythmic process)
GO:0048643 (positive regulation of skeletal muscle tissue development)
GO:0050995 (negative regulation of lipid catabolic process)
GO:0051291 (protein heterooligomerization)
GO:0055089 (fatty acid homeostasis)
GO:0060627 (regulation of vesicle-mediated transport)
GO:0061762 (CAMKK-AMPK signaling cascade)
GO:0070301 (cellular response to hydrogen peroxide)
GO:0070507 (regulation of microtubule cytoskeleton organization)
GO:0071277 (cellular response to calcium ion)
GO:0071333 (cellular response to glucose stimulus)
GO:0071361 (cellular response to ethanol)
GO:0071380 (cellular response to prostaglandin E stimulus)
GO:0071417 (cellular response to organonitrogen compound)
GO:0071456 (cellular response to hypoxia)
GO:0097009 (energy homeostasis)
GO:1901563 (response to camptothecin)
GO:1901796 (regulation of signal transduction by p53 class mediator)
GO:1903109 (positive regulation of mitochondrial transcription)
GO:1903829 (positive regulation of cellular protein localization)
GO:1903955 (positive regulation of protein targeting to mitochondrion)
GO:1904428 (negative regulation of tubulin deacetylation)
GO:2000758 (positive regulation of peptidyl-lysine acetylation)
GO:2001274 (negative regulation of glucose import in response to insulin stimulus)
Wikipedia Protein_kinase,_AMP-activated,_alpha_1

Target Cross References - Protein

canSAR Q13131
Human Protein Atlas ENSG00000132356
IntAct Q13131
Guide to Pharmacology 1541
Open Targets ENSG00000132356
PharmGKB PA33744
Pharos Q13131 (Tchem)
Reactome R-HSA-1632852 (Macroautophagy.)
R-HSA-380972 (Energy dependent regulation of mTOR by LKB1-AMPK.)
R-HSA-5628897 (TP53 Regulates Metabolic Genes.)
R-HSA-6804756 (Regulation of TP53 Activity through Phosphorylation.)
UniProt A8MTQ6 B2R7E1 O00286 Q13131 Q5D0E1 Q86VS1 Q9UNQ4

Target Cross References - Domain

InterPro IPR000719 (Prot_kinase_dom.)
IPR008271 (Ser/Thr_kinase_AS.)
IPR011009 (Kinase-like_dom_sf.)
IPR017441 (Protein_kinase_ATP_BS.)
IPR028375 (KA1/Ssp2_C.)
IPR032270 (AMPK_C.)
Pfam PF00069 (Pkinase)
PF16579 (AdenylateSensor)

Target Cross References - Structure