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ChEMBL

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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL4042
Target Type SINGLE PROTEIN
Preferred Name Cyclooxygenase-1
Synonyms COX-1 | Cox-1 | Cox1 | Cyclooxygenase-1 | PGH synthase 1 | PGHS-1 | PHS 1 | Prostaglandin G/H synthase 1 | Prostaglandin H2 synthase 1 | Prostaglandin-endoperoxide synthase 1 | Ptgs1
Organism Rattus norvegicus
Species Group No
Protein Target Classification
  • enzyme

Target Components

Component Description Relationship Accession
Prostaglandin G/H synthase 1 SINGLE PROTEIN Q63921

Target Relations

ChEMBL ID Pref Name Target Type
CHEMBL2095157 Cyclooxygenase PROTEIN FAMILY

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

GO Cellular Component GO:0005635 (nuclear envelope)
GO:0005737 (cytoplasm)
GO:0005783 (endoplasmic reticulum)
GO:0005789 (endoplasmic reticulum membrane)
GO:0016020 (membrane)
GO:0031090 (organelle membrane)
GO:0043231 (intracellular membrane-bounded organelle)
GO Molecular Function GO:0004601 (peroxidase activity)
GO:0004666 (prostaglandin-endoperoxide synthase activity)
GO:0016491 (oxidoreductase activity)
GO:0020037 (heme binding)
GO:0046872 (metal ion binding)
GO:0051213 (dioxygenase activity)
GO Biological Process GO:0001516 (prostaglandin biosynthetic process)
GO:0006629 (lipid metabolic process)
GO:0006631 (fatty acid metabolic process)
GO:0006633 (fatty acid biosynthetic process)
GO:0006693 (prostaglandin metabolic process)
GO:0006954 (inflammatory response)
GO:0006979 (response to oxidative stress)
GO:0007568 (aging)
GO:0007612 (learning)
GO:0007613 (memory)
GO:0008217 (regulation of blood pressure)
GO:0010243 (response to organonitrogen compound)
GO:0010700 (negative regulation of norepinephrine secretion)
GO:0019233 (sensory perception of pain)
GO:0019371 (cyclooxygenase pathway)
GO:0032811 (negative regulation of epinephrine secretion)
GO:0035633 (maintenance of blood-brain barrier)
GO:0045907 (positive regulation of vasoconstriction)
GO:0045987 (positive regulation of smooth muscle contraction)
GO:0051412 (response to corticosterone)
GO:0055114 (oxidation-reduction process)
GO:0070542 (response to fatty acid)
GO:0097756 (negative regulation of blood vessel diameter)
GO:0098869 (cellular oxidant detoxification)

Target Cross References - Protein

canSAR Q63921
IntAct Q63921
UniProt Q62731 Q63684 Q63921

Target Cross References - Domain

InterPro IPR000742 (EGF-like_dom.)
IPR010255 (Haem_peroxidase.)
IPR019791 (Haem_peroxidase_animal.)
IPR029580 (COX-1.)
IPR037120 (Haem_peroxidase_sf.)
Pfam PF03098 (An_peroxidase)
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