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Target Report Card

Target Name and Classification

Target ID CHEMBL4036
Preferred Name Cyclin-dependent kinase 5
Synonyms CDK5 | CDKN5 | Cell division protein kinase 5 | Cyclin-dependent-like kinase 5 | Serine/threonine-protein kinase PSSALRE | TPKII catalytic subunit | Tau protein kinase II catalytic subunit
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme > kinase > protein kinase > cmgc protein kinase group > cmgc protein kinase cdk family > cmgc protein kinase cdk5 subfamily

Target Components

Component Description Relationship Accession
Cyclin-dependent-like kinase 5 SINGLE PROTEIN Q00535

Target Relations

ChEMBL ID Pref Name Target Type
CHEMBL3559691 Cyclin-dependent kinase PROTEIN FAMILY
CHEMBL3885549 Cyclin-T1/Cyclin-dependent-like kinase 5 PROTEIN COMPLEX
CHEMBL1907600 Cyclin-dependent kinase 5/CDK5 activator 1 PROTEIN COMPLEX

Approved Drugs and Clinical Candidates

ChEMBL ID Name Mechanism of Action Max Phase References
CHEMBL2103840 DINACICLIB Cyclin-dependent kinase 5 inhibitor 3 PubMed
CHEMBL14762 SELICICLIB Cyclin-dependent kinase 5 inhibitor 2 PubMed PubMed PubMed
CHEMBL3545083 RGB-286638 Cyclin-dependent kinase 5 inhibitor 1 PubMed

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000164885
Ensembl ENSG00000164885
GO Cellular Component GO:0005634 (nucleus)
GO:0005654 (nucleoplasm)
GO:0005737 (cytoplasm)
GO:0005829 (cytosol)
GO:0005856 (cytoskeleton)
GO:0005874 (microtubule)
GO:0005886 (plasma membrane)
GO:0014069 (postsynaptic density)
GO:0016020 (membrane)
GO:0016533 (cyclin-dependent protein kinase 5 holoenzyme complex)
GO:0030027 (lamellipodium)
GO:0030054 (cell junction)
GO:0030175 (filopodium)
GO:0030424 (axon)
GO:0030425 (dendrite)
GO:0030426 (growth cone)
GO:0031594 (neuromuscular junction)
GO:0042995 (cell projection)
GO:0043025 (neuronal cell body)
GO:0043204 (perikaryon)
GO:0045202 (synapse)
GO:0045211 (postsynaptic membrane)
GO:0098793 (presynapse)
GO Molecular Function GO:0000166 (nucleotide binding)
GO:0002039 (p53 binding)
GO:0004672 (protein kinase activity)
GO:0004674 (protein serine/threonine kinase activity)
GO:0004693 (cyclin-dependent protein serine/threonine kinase activity)
GO:0005176 (ErbB-2 class receptor binding)
GO:0005515 (protein binding)
GO:0005524 (ATP binding)
GO:0008017 (microtubule binding)
GO:0008092 (cytoskeletal protein binding)
GO:0016301 (kinase activity)
GO:0016740 (transferase activity)
GO:0019901 (protein kinase binding)
GO:0030549 (acetylcholine receptor activator activity)
GO:0043125 (ErbB-3 class receptor binding)
GO:0046875 (ephrin receptor binding)
GO:0050321 (tau-protein kinase activity)
GO:0051879 (Hsp90 protein binding)
GO Biological Process GO:0000226 (microtubule cytoskeleton organization)
GO:0001764 (neuron migration)
GO:0001934 (positive regulation of protein phosphorylation)
GO:0001963 (synaptic transmission, dopaminergic)
GO:0006468 (protein phosphorylation)
GO:0006886 (intracellular protein transport)
GO:0006887 (exocytosis)
GO:0006913 (nucleocytoplasmic transport)
GO:0006915 (apoptotic process)
GO:0007005 (mitochondrion organization)
GO:0007049 (cell cycle)
GO:0007160 (cell-matrix adhesion)
GO:0007268 (chemical synaptic transmission)
GO:0007399 (nervous system development)
GO:0007409 (axonogenesis)
GO:0007416 (synapse assembly)
GO:0007519 (skeletal muscle tissue development)
GO:0008045 (motor neuron axon guidance)
GO:0008283 (cell proliferation)
GO:0008306 (associative learning)
GO:0008542 (visual learning)
GO:0009611 (response to wounding)
GO:0014044 (Schwann cell development)
GO:0016079 (synaptic vesicle exocytosis)
GO:0016241 (regulation of macroautophagy)
GO:0016310 (phosphorylation)
GO:0016477 (cell migration)
GO:0018105 (peptidyl-serine phosphorylation)
GO:0018107 (peptidyl-threonine phosphorylation)
GO:0019233 (sensory perception of pain)
GO:0021537 (telencephalon development)
GO:0021549 (cerebellum development)
GO:0021695 (cerebellar cortex development)
GO:0021697 (cerebellar cortex formation)
GO:0021766 (hippocampus development)
GO:0021819 (layer formation in cerebral cortex)
GO:0021954 (central nervous system neuron development)
GO:0021987 (cerebral cortex development)
GO:0022038 (corpus callosum development)
GO:0030182 (neuron differentiation)
GO:0030334 (regulation of cell migration)
GO:0030517 (negative regulation of axon extension)
GO:0030866 (cortical actin cytoskeleton organization)
GO:0030900 (forebrain development)
GO:0031175 (neuron projection development)
GO:0031397 (negative regulation of protein ubiquitination)
GO:0031914 (negative regulation of synaptic plasticity)
GO:0032092 (positive regulation of protein binding)
GO:0032801 (receptor catabolic process)
GO:0034352 (positive regulation of glial cell apoptotic process)
GO:0035249 (synaptic transmission, glutamatergic)
GO:0035418 (protein localization to synapse)
GO:0042220 (response to cocaine)
GO:0042501 (serine phosphorylation of STAT protein)
GO:0042981 (regulation of apoptotic process)
GO:0043113 (receptor clustering)
GO:0043525 (positive regulation of neuron apoptotic process)
GO:0045055 (regulated exocytosis)
GO:0045786 (negative regulation of cell cycle)
GO:0045860 (positive regulation of protein kinase activity)
GO:0045861 (negative regulation of proteolysis)
GO:0045892 (negative regulation of transcription, DNA-templated)
GO:0045956 (positive regulation of calcium ion-dependent exocytosis)
GO:0046777 (protein autophosphorylation)
GO:0046826 (negative regulation of protein export from nucleus)
GO:0048148 (behavioral response to cocaine)
GO:0048167 (regulation of synaptic plasticity)
GO:0048488 (synaptic vesicle endocytosis)
GO:0048511 (rhythmic process)
GO:0048675 (axon extension)
GO:0048709 (oligodendrocyte differentiation)
GO:0048812 (neuron projection morphogenesis)
GO:0048813 (dendrite morphogenesis)
GO:0051301 (cell division)
GO:0051402 (neuron apoptotic process)
GO:0051966 (regulation of synaptic transmission, glutamatergic)
GO:0060078 (regulation of postsynaptic membrane potential)
GO:0060079 (excitatory postsynaptic potential)
GO:0061001 (regulation of dendritic spine morphogenesis)
GO:0070509 (calcium ion import)
GO:0071156 (regulation of cell cycle arrest)
GO:0090314 (positive regulation of protein targeting to membrane)
GO:1901215 (negative regulation of neuron death)
GO:1901216 (positive regulation of neuron death)
GO:1901796 (regulation of signal transduction by p53 class mediator)
GO:1903076 (regulation of protein localization to plasma membrane)
GO:1903421 (regulation of synaptic vesicle recycling)
GO:1904646 (cellular response to beta-amyloid)
GO:2000251 (positive regulation of actin cytoskeleton reorganization)
GO:2000273 (positive regulation of receptor activity)
Wikipedia Cyclin-dependent_kinase_5

Target Cross References - Protein

canSAR Q00535
Human Protein Atlas ENSG00000164885
IntAct Q00535
Guide to Pharmacology 1977
Open Targets ENSG00000164885
PharmGKB PA26310
Pharos Q00535 (Tchem)
Reactome R-HSA-180024 (DARPP-32 events.)
R-HSA-399956 (CRMPs in Sema3A signaling.)
R-HSA-6804756 (Regulation of TP53 Activity through Phosphorylation.)
R-HSA-8862803 (Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models.)
R-HSA-983231 (Factors involved in megakaryocyte development and platelet production.)
UniProt A1XKG3 Q00535

Target Cross References - Domain

InterPro IPR000719 (Prot_kinase_dom.)
IPR008271 (Ser/Thr_kinase_AS.)
IPR011009 (Kinase-like_dom_sf.)
IPR017441 (Protein_kinase_ATP_BS.)
Pfam PF00069 (Pkinase)

Target Cross References - Structure