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Target Report Card

Target Name and Classification

Target ID CHEMBL4031
Preferred Name Beta-3 adrenergic receptor
Synonyms Adrb3 | Adrb3r | Beta-3 adrenergic receptor | Beta-3 adrenoceptor | Beta-3 adrenoreceptor
Organism Rattus norvegicus
Species Group No
Protein Target Classification
  • membrane receptor > family a g protein-coupled receptor > small molecule receptor (family a gpcr) > monoamine receptor > adrenergic receptor

Target Components

Component Description Relationship Accession
Beta-3 adrenergic receptor SINGLE PROTEIN P26255

Target Relations

ChEMBL ID Pref Name Target Type
CHEMBL2095166 Adrenergic receptor beta PROTEIN FAMILY

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

GO Cellular Component GO:0005634 (nucleus)
GO:0005886 (plasma membrane)
GO:0005887 (integral component of plasma membrane)
GO:0016020 (membrane)
GO:0016021 (integral component of membrane)
GO:0043235 (receptor complex)
GO Molecular Function GO:0004871 (signal transducer activity)
GO:0004930 (G-protein coupled receptor activity)
GO:0004935 (adrenergic receptor activity)
GO:0004939 (beta-adrenergic receptor activity)
GO:0015052 (beta3-adrenergic receptor activity)
GO:0031699 (beta-3 adrenergic receptor binding)
GO:0042803 (protein homodimerization activity)
GO:0051379 (epinephrine binding)
GO:0051380 (norepinephrine binding)
GO Biological Process GO:0001659 (temperature homeostasis)
GO:0002024 (diet induced thermogenesis)
GO:0002025 (vasodilation by norepinephrine-epinephrine involved in regulation of systemic arterial blood pressure)
GO:0007165 (signal transduction)
GO:0007186 (G-protein coupled receptor signaling pathway)
GO:0007189 (adenylate cyclase-activating G-protein coupled receptor signaling pathway)
GO:0007190 (activation of adenylate cyclase activity)
GO:0007267 (cell-cell signaling)
GO:0007568 (aging)
GO:0009409 (response to cold)
GO:0031649 (heat generation)
GO:0040015 (negative regulation of multicellular organism growth)
GO:0042755 (eating behavior)
GO:0043410 (positive regulation of MAPK cascade)
GO:0046677 (response to antibiotic)
GO:0050873 (brown fat cell differentiation)
GO:0071880 (adenylate cyclase-activating adrenergic receptor signaling pathway)

Target Cross References - Protein

canSAR P26255
Guide to Pharmacology 30
Reactome R-RNO-390696 (Adrenoceptors.)
R-RNO-418555 (G alpha (s) signalling events.)
UniProt P26255

Target Cross References - Domain

InterPro IPR000276 (GPCR_Rhodpsn.)
IPR000681 (ADRB3_rcpt.)
IPR002233 (ADR_fam.)
IPR017452 (GPCR_Rhodpsn_7TM.)
Pfam PF00001 (7tm_1)