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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL4030
Target Type SINGLE PROTEIN
Preferred Name Beta-3 adrenergic receptor
Synonyms Adrb3 | Adrb3r | B3bar | Beta-3 adrenergic receptor | Beta-3 adrenoceptor | Beta-3 adrenoreceptor
Organism Mus musculus
Species Group No
Protein Target Classification
  • membrane receptor > family a g protein-coupled receptor > small molecule receptor (family a gpcr) > monoamine receptor > adrenergic receptor

Target Components

Component Description Relationship Accession
Beta-3 adrenergic receptor SINGLE PROTEIN P25962

Target Relations

ChEMBL ID Pref Name Target Type
CHEMBL2111395 Beta-adrenergic receptor PROTEIN FAMILY

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

GO Cellular Component GO:0005634 (nucleus)
GO:0005886 (plasma membrane)
GO:0005887 (integral component of plasma membrane)
GO:0016020 (membrane)
GO:0016021 (integral component of membrane)
GO:0043235 (receptor complex)
GO Molecular Function GO:0004871 (signal transducer activity)
GO:0004930 (G-protein coupled receptor activity)
GO:0004935 (adrenergic receptor activity)
GO:0004939 (beta-adrenergic receptor activity)
GO:0015052 (beta3-adrenergic receptor activity)
GO:0031699 (beta-3 adrenergic receptor binding)
GO:0042803 (protein homodimerization activity)
GO:0051379 (epinephrine binding)
GO:0051380 (norepinephrine binding)
GO Biological Process GO:0002024 (diet induced thermogenesis)
GO:0002025 (vasodilation by norepinephrine-epinephrine involved in regulation of systemic arterial blood pressure)
GO:0007165 (signal transduction)
GO:0007186 (G-protein coupled receptor signaling pathway)
GO:0007189 (adenylate cyclase-activating G-protein coupled receptor signaling pathway)
GO:0007190 (activation of adenylate cyclase activity)
GO:0007267 (cell-cell signaling)
GO:0007568 (aging)
GO:0009409 (response to cold)
GO:0031649 (heat generation)
GO:0040015 (negative regulation of multicellular organism growth)
GO:0042755 (eating behavior)
GO:0043410 (positive regulation of MAPK cascade)
GO:0046677 (response to antibiotic)
GO:0050873 (brown fat cell differentiation)
GO:0071880 (adenylate cyclase-activating adrenergic receptor signaling pathway)

Target Cross References - Protein

canSAR P25962
IntAct P25962
Guide to Pharmacology 30
Reactome R-MMU-390696 (Adrenoceptors.)
R-MMU-418555 (G alpha (s) signalling events.)
UniProt A2RS74 P25962 Q9QZ98

Target Cross References - Domain

InterPro IPR000276 (GPCR_Rhodpsn.)
IPR000681 (ADRB3_rcpt.)
IPR002233 (ADR_fam.)
IPR017452 (GPCR_Rhodpsn_7TM.)
Pfam PF00001 (7tm_1)
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