ChEMBL logo

ChEMBL

spacer
ChEMBL Statistics
  Loading Statistics...
spacer

Target Report Card

Target Name and Classification

Target ID CHEMBL401
Target Type SINGLE PROTEIN
Preferred Name Glutamate [NMDA] receptor subunit epsilon 3
Synonyms GluN2C | Glutamate [NMDA] receptor subunit epsilon-3 | Glutamate receptor ionotropic, NMDA 2C | Grin2c | N-methyl D-aspartate receptor subtype 2C | NMDAR2C | NR2C
Organism Rattus norvegicus
Species Group No
Protein Target Classification
  • ion channel > ligand-gated ion channel > ionotropic glutamate receptor > nmda receptor

Target Components

Component Description Relationship Accession
Glutamate receptor ionotropic, NMDA 2C SINGLE PROTEIN Q00961

Target Relations

ChEMBL ID Pref Name Target Type
CHEMBL2096911 Glutamate NMDA receptor; Grin1/Grin2c PROTEIN COMPLEX
CHEMBL2096669 Glutamate receptors; NMDA/AMPA PROTEIN COMPLEX GROUP
CHEMBL1907608 Glutamate NMDA receptor PROTEIN COMPLEX GROUP

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

GO Cellular Component GO:0005622 (intracellular)
GO:0005886 (plasma membrane)
GO:0016020 (membrane)
GO:0016021 (integral component of membrane)
GO:0017146 (NMDA selective glutamate receptor complex)
GO:0030054 (cell junction)
GO:0045202 (synapse)
GO:0045211 (postsynaptic membrane)
GO Molecular Function GO:0004970 (ionotropic glutamate receptor activity)
GO:0004972 (NMDA glutamate receptor activity)
GO:0005216 (ion channel activity)
GO:0005234 (extracellular-glutamate-gated ion channel activity)
GO:0005261 (cation channel activity)
GO:0005515 (protein binding)
GO:0022849 (glutamate-gated calcium ion channel activity)
GO:0030165 (PDZ domain binding)
GO:0038023 (signaling receptor activity)
GO:0047485 (protein N-terminus binding)
GO Biological Process GO:0006811 (ion transport)
GO:0007165 (signal transduction)
GO:0019722 (calcium-mediated signaling)
GO:0035235 (ionotropic glutamate receptor signaling pathway)
GO:0060079 (excitatory postsynaptic potential)
GO:0097553 (calcium ion transmembrane import into cytosol)

Target Cross References - Protein

canSAR Q00961
IntAct Q00961
Guide to Pharmacology 458
UniProt Q00961

Target Cross References - Domain

InterPro IPR001320 (Iontro_rcpt.)
IPR001508 (Iono_rcpt_met.)
IPR001828 (ANF_lig-bd_rcpt.)
IPR018884 (NMDAR2_C.)
IPR019594 (Glu/Gly-bd.)
IPR028082 (Peripla_BP_I.)
Pfam PF00060 (Lig_chan)
PF01094 (ANF_receptor)
PF10565 (NMDAR2_C)
PF10613 (Lig_chan-Glu_bd)
spacer
spacer