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Target Report Card

Target Name and Classification

Target ID CHEMBL4000
Preferred Name Muscle glycogen synthase
Synonyms GYS | GYS1 | Glycogen [starch] synthase, muscle
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme

Target Components

Component Description Relationship Accession
Glycogen [starch] synthase, muscle SINGLE PROTEIN P13807

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000104812
Ensembl ENSG00000104812
GO Cellular Component GO:0005737 (cytoplasm)
GO:0005829 (cytosol)
GO:0016020 (membrane)
GO:0016234 (inclusion body)
GO Molecular Function GO:0003824 (catalytic activity)
GO:0004373 (glycogen (starch) synthase activity)
GO:0005515 (protein binding)
GO:0005536 (glucose binding)
GO:0016740 (transferase activity)
GO:0016757 (transferase activity, transferring glycosyl groups)
GO:0019901 (protein kinase binding)
GO:0061547 (glycogen synthase activity, transferring glucose-1-phosphate)
GO Biological Process GO:0005977 (glycogen metabolic process)
GO:0005978 (glycogen biosynthetic process)
GO:0007507 (heart development)
GO:0008152 (metabolic process)

Target Cross References - Protein

canSAR P13807
CGD Glycogen storage disease 0, muscle
Human Protein Atlas ENSG00000104812
IntAct P13807
Open Targets ENSG00000104812
PharmGKB PA29084
Reactome R-HSA-3322077 (Glycogen synthesis.)
R-HSA-3785653 (Myoclonic epilepsy of Lafora.)
R-HSA-3814836 (Glycogen storage disease type XV (GYG1).)
R-HSA-3828062 (Glycogen storage disease type 0 (muscle GYS1).)
R-HSA-3878781 (Glycogen storage disease type IV (GBE1).)
UniProt P13807 Q9BTT9

Target Cross References - Domain

InterPro IPR008631 (Glycogen_synth.)
Pfam PF05693 (Glycogen_syn)