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Target Report Card

Target Name and Classification

Target ID CHEMBL3988
Preferred Name Ephrin type-A receptor 4
Synonyms EK8 | EPH-like kinase 8 | EPHA4 | Ephrin type-A receptor 4 | HEK8 | SEK | TYRO1 | Tyrosine-protein kinase TYRO1 | Tyrosine-protein kinase receptor SEK | hEK8
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme > kinase > protein kinase > tk protein kinase group > tyrosine protein kinase eph family

Target Components

Component Description Relationship Accession
Ephrin type-A receptor 4 SINGLE PROTEIN P54764

Target Relations

ChEMBL ID Pref Name Target Type
CHEMBL2363043 Ephrin receptor PROTEIN FAMILY

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000116106
Ensembl ENSG00000116106
GO Cellular Component GO:0005737 (cytoplasm)
GO:0005741 (mitochondrial outer membrane)
GO:0005768 (endosome)
GO:0005769 (early endosome)
GO:0005783 (endoplasmic reticulum)
GO:0005794 (Golgi apparatus)
GO:0005886 (plasma membrane)
GO:0005887 (integral component of plasma membrane)
GO:0009986 (cell surface)
GO:0014069 (postsynaptic density)
GO:0016020 (membrane)
GO:0016021 (integral component of membrane)
GO:0030054 (cell junction)
GO:0030175 (filopodium)
GO:0030424 (axon)
GO:0030425 (dendrite)
GO:0031594 (neuromuscular junction)
GO:0031901 (early endosome membrane)
GO:0042995 (cell projection)
GO:0043197 (dendritic spine)
GO:0043198 (dendritic shaft)
GO:0043204 (perikaryon)
GO:0043679 (axon terminus)
GO:0044295 (axonal growth cone)
GO:0044297 (cell body)
GO:0045202 (synapse)
GO:0045211 (postsynaptic membrane)
GO Molecular Function GO:0000166 (nucleotide binding)
GO:0004672 (protein kinase activity)
GO:0004713 (protein tyrosine kinase activity)
GO:0004714 (transmembrane receptor protein tyrosine kinase activity)
GO:0005003 (ephrin receptor activity)
GO:0005004 (GPI-linked ephrin receptor activity)
GO:0005005 (transmembrane-ephrin receptor activity)
GO:0005515 (protein binding)
GO:0005524 (ATP binding)
GO:0016301 (kinase activity)
GO:0016740 (transferase activity)
GO:0042731 (PH domain binding)
GO:0042802 (identical protein binding)
GO:0046875 (ephrin receptor binding)
GO:0097161 (DH domain binding)
GO:1990782 (protein tyrosine kinase binding)
GO Biological Process GO:0006468 (protein phosphorylation)
GO:0007155 (cell adhesion)
GO:0007169 (transmembrane receptor protein tyrosine kinase signaling pathway)
GO:0007275 (multicellular organism development)
GO:0007399 (nervous system development)
GO:0007411 (axon guidance)
GO:0007628 (adult walking behavior)
GO:0008045 (motor neuron axon guidance)
GO:0008347 (glial cell migration)
GO:0010977 (negative regulation of neuron projection development)
GO:0016310 (phosphorylation)
GO:0018108 (peptidyl-tyrosine phosphorylation)
GO:0021957 (corticospinal tract morphogenesis)
GO:0043087 (regulation of GTPase activity)
GO:0043507 (positive regulation of JUN kinase activity)
GO:0046777 (protein autophosphorylation)
GO:0048013 (ephrin receptor signaling pathway)
GO:0048681 (negative regulation of axon regeneration)
GO:0048710 (regulation of astrocyte differentiation)
GO:0050770 (regulation of axonogenesis)
GO:0050775 (positive regulation of dendrite morphogenesis)
GO:0050821 (protein stabilization)
GO:0061001 (regulation of dendritic spine morphogenesis)
GO:0061098 (positive regulation of protein tyrosine kinase activity)
GO:0072178 (nephric duct morphogenesis)
GO:0097155 (fasciculation of sensory neuron axon)
GO:0097156 (fasciculation of motor neuron axon)
GO:0097485 (neuron projection guidance)
GO:0106030 (neuron projection fasciculation)
GO:1900272 (negative regulation of long-term synaptic potentiation)
GO:1902004 (positive regulation of beta-amyloid formation)
GO:1902961 (positive regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process)
GO:1903051 (negative regulation of proteolysis involved in cellular protein catabolic process)
GO:1904646 (cellular response to beta-amyloid)
GO:1905244 (regulation of modification of synaptic structure)
GO:2001108 (positive regulation of Rho guanyl-nucleotide exchange factor activity)
Wikipedia EPH_receptor_A4

Target Cross References - Protein

canSAR P54764
Human Protein Atlas ENSG00000116106
IntAct P54764
Guide to Pharmacology 1824
Open Targets ENSG00000116106
PharmGKB PA27820
Pharos P54764 (Tchem)
Reactome R-HSA-2682334 (EPH-Ephrin signaling.)
R-HSA-3928663 (EPHA-mediated growth cone collapse.)
R-HSA-3928665 (EPH-ephrin mediated repulsion of cells.)
UniProt A8K2P1 B2R601 B7Z6Q8 P54764 Q2M380

Target Cross References - Domain

InterPro IPR000719 (Prot_kinase_dom.)
IPR001090 (Ephrin_rcpt_lig-bd_dom.)
IPR001245 (Ser-Thr/Tyr_kinase_cat_dom.)
IPR001426 (Tyr_kinase_rcpt_V_CS.)
IPR001660 (SAM.)
IPR003961 (FN3_dom.)
IPR008266 (Tyr_kinase_AS.)
IPR008979 (Galactose-bd-like_sf.)
IPR011009 (Kinase-like_dom_sf.)
IPR011641 (Tyr-kin_ephrin_A/B_rcpt-like.)
IPR013761 (SAM/pointed_sf.)
IPR013783 (Ig-like_fold.)
IPR016257 (Tyr_kinase_ephrin_rcpt.)
IPR017441 (Protein_kinase_ATP_BS.)
IPR020635 (Tyr_kinase_cat_dom.)
IPR027936 (Eph_TM.)
IPR034270 (EphA4_rcpt_lig-bd.)
IPR036116 (FN3_sf.)
Pfam PF00041 (fn3)
PF01404 (Ephrin_lbd)
PF07647 (SAM_2)
PF07714 (Pkinase_Tyr)
PF14575 (EphA2_TM)

Target Cross References - Structure

PDBe 2WO1 2WO2 2WO3 3CKH 3GXU 4BK4 4BK5 4BKA 4BKF 4M4P 4M4R 4W4Z 4W50 5JR2
CREDO 2WO1 2WO2 2WO3 3CKH 3GXU 4BK4 4BK5 4BKA 4BKF 4M4P 4M4R 4W4Z 4W50 5JR2