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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL3983
Target Type SINGLE PROTEIN
Preferred Name Dual specificity protein kinase TTK
Synonyms Dual specificity protein kinase TTK | MPS1 | MPS1L1 | PYT | Phosphotyrosine picked threonine-protein kinase | TTK
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme > kinase > protein kinase > other protein kinase group > other protein kinase ttk family

Target Components

Component Description Relationship Accession
Dual specificity protein kinase TTK SINGLE PROTEIN P33981

Approved Drugs and Clinical Candidates

ChEMBL ID Name Mechanism of Action Max Phase References
CHEMBL3544955 BAY-1217389 Dual specificity protein kinase TTK inhibitor 1 DOI
CHEMBL3545425 BAY-1161909 Dual specificity protein kinase TTK inhibitor 1 DOI

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000112742
Ensembl ENSG00000112742
GO Cellular Component GO:0000776 (kinetochore)
GO:0005737 (cytoplasm)
GO:0005819 (spindle)
GO:0016020 (membrane)
GO Molecular Function GO:0000166 (nucleotide binding)
GO:0004672 (protein kinase activity)
GO:0004674 (protein serine/threonine kinase activity)
GO:0004712 (protein serine/threonine/tyrosine kinase activity)
GO:0004713 (protein tyrosine kinase activity)
GO:0005515 (protein binding)
GO:0005524 (ATP binding)
GO:0016301 (kinase activity)
GO:0016740 (transferase activity)
GO:0042803 (protein homodimerization activity)
GO Biological Process GO:0006468 (protein phosphorylation)
GO:0007051 (spindle organization)
GO:0007052 (mitotic spindle organization)
GO:0007093 (mitotic cell cycle checkpoint)
GO:0007094 (mitotic spindle assembly checkpoint)
GO:0008284 (positive regulation of cell proliferation)
GO:0010862 (positive regulation of pathway-restricted SMAD protein phosphorylation)
GO:0016310 (phosphorylation)
GO:0016321 (female meiosis chromosome segregation)
GO:0018105 (peptidyl-serine phosphorylation)
GO:0018107 (peptidyl-threonine phosphorylation)
GO:0018108 (peptidyl-tyrosine phosphorylation)
GO:0033316 (meiotic spindle assembly checkpoint)
GO:0034501 (protein localization to kinetochore)
GO:0034502 (protein localization to chromosome)
GO:0046777 (protein autophosphorylation)
GO:0051304 (chromosome separation)
GO:1903096 (protein localization to meiotic spindle midzone)
Wikipedia TTK_(gene)

Target Cross References - Protein

canSAR P33981
Human Protein Atlas ENSG00000112742
IntAct P33981
Guide to Pharmacology 2264
Open Targets ENSG00000112742
PharmGKB PA37066
Pharos P33981 (Tchem)
UniProt A8K8U5 B2RDW2 E1P543 P33981 Q15272 Q5TCS0 Q9BW51 Q9NTM0

Target Cross References - Domain

InterPro IPR000719 (Prot_kinase_dom.)
IPR008271 (Ser/Thr_kinase_AS.)
IPR011009 (Kinase-like_dom_sf.)
IPR011990 (TPR-like_helical_dom_sf.)
IPR017441 (Protein_kinase_ATP_BS.)
IPR027084 (Prot_kin_Mps1_fam.)
Pfam PF00069 (Pkinase)

Target Cross References - Structure

PDBe 2X9E 2ZMC 2ZMD 3CEK 3DBQ 3GFW 3H9F 3HMN 3HMO 3HMP 3VQU 3W1F 3WYX 3WYY 3WZJ 3WZK 4B94 4BHZ 4BI0 4BI1 4BI2 4C4E 4C4F 4C4G More...
CREDO 2X9E 2ZMC 2ZMD 3CEK 3DBQ 3GFW 3H9F 3HMN 3HMO 3HMP 3VQU 3W1F 3WYX 3WYY 3WZJ 3WZK 4B94 4BHZ 4BI0 4BI1 4BI2 4C4E 4C4F 4C4G More...
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