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Target Report Card

Target Name and Classification

Target ID CHEMBL3982
Preferred Name Tyrosine-protein kinase FER
Synonyms FER | Feline encephalitis virus-related kinase FER | Fujinami poultry sarcoma/Feline sarcoma-related protein Fer | Proto-oncogene c-Fer | TYK3 | Tyrosine kinase 3 | Tyrosine-protein kinase Fer | p94-Fer
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme > kinase > protein kinase > tk protein kinase group > tyrosine protein kinase fer family

Target Components

Component Description Relationship Accession
Tyrosine-protein kinase Fer SINGLE PROTEIN P16591

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000151422
Ensembl ENSG00000151422
GO Cellular Component GO:0000790 (nuclear chromatin)
GO:0005634 (nucleus)
GO:0005737 (cytoplasm)
GO:0005829 (cytosol)
GO:0005856 (cytoskeleton)
GO:0005886 (plasma membrane)
GO:0005938 (cell cortex)
GO:0015629 (actin cytoskeleton)
GO:0015630 (microtubule cytoskeleton)
GO:0016020 (membrane)
GO:0030027 (lamellipodium)
GO:0030054 (cell junction)
GO:0031234 (extrinsic component of cytoplasmic side of plasma membrane)
GO:0042995 (cell projection)
GO Molecular Function GO:0000166 (nucleotide binding)
GO:0004672 (protein kinase activity)
GO:0004713 (protein tyrosine kinase activity)
GO:0004715 (non-membrane spanning protein tyrosine kinase activity)
GO:0005154 (epidermal growth factor receptor binding)
GO:0005515 (protein binding)
GO:0005524 (ATP binding)
GO:0008157 (protein phosphatase 1 binding)
GO:0008289 (lipid binding)
GO:0016301 (kinase activity)
GO:0016740 (transferase activity)
GO Biological Process GO:0000226 (microtubule cytoskeleton organization)
GO:0000278 (mitotic cell cycle)
GO:0001932 (regulation of protein phosphorylation)
GO:0006468 (protein phosphorylation)
GO:0006935 (chemotaxis)
GO:0007155 (cell adhesion)
GO:0007165 (signal transduction)
GO:0007260 (tyrosine phosphorylation of STAT protein)
GO:0008283 (cell proliferation)
GO:0008284 (positive regulation of cell proliferation)
GO:0010591 (regulation of lamellipodium assembly)
GO:0010762 (regulation of fibroblast migration)
GO:0016310 (phosphorylation)
GO:0018108 (peptidyl-tyrosine phosphorylation)
GO:0019221 (cytokine-mediated signaling pathway)
GO:0030154 (cell differentiation)
GO:0030335 (positive regulation of cell migration)
GO:0030838 (positive regulation of actin filament polymerization)
GO:0031532 (actin cytoskeleton reorganization)
GO:0032496 (response to lipopolysaccharide)
GO:0032869 (cellular response to insulin stimulus)
GO:0033007 (negative regulation of mast cell activation involved in immune response)
GO:0034446 (substrate adhesion-dependent cell spreading)
GO:0034614 (cellular response to reactive oxygen species)
GO:0035426 (extracellular matrix-cell signaling)
GO:0035556 (intracellular signal transduction)
GO:0036006 (cellular response to macrophage colony-stimulating factor stimulus)
GO:0036119 (response to platelet-derived growth factor)
GO:0038028 (insulin receptor signaling pathway via phosphatidylinositol 3-kinase)
GO:0038083 (peptidyl-tyrosine autophosphorylation)
GO:0038095 (Fc-epsilon receptor signaling pathway)
GO:0038109 (Kit signaling pathway)
GO:0042058 (regulation of epidermal growth factor receptor signaling pathway)
GO:0043304 (regulation of mast cell degranulation)
GO:0044331 (cell-cell adhesion mediated by cadherin)
GO:0045087 (innate immune response)
GO:0046777 (protein autophosphorylation)
GO:0048008 (platelet-derived growth factor receptor signaling pathway)
GO:0050904 (diapedesis)
GO:0051092 (positive regulation of NF-kappaB transcription factor activity)
GO:0070102 (interleukin-6-mediated signaling pathway)
Wikipedia FER_(gene)

Target Cross References - Protein

canSAR P16591
Human Protein Atlas ENSG00000151422
IntAct P16591
Guide to Pharmacology 2022
Open Targets ENSG00000151422
PharmGKB PA28095
Pharos P16591 (Tchem)
Reactome R-HSA-1433557 (Signaling by SCF-KIT.)
UniProt B2RCR4 B4DSQ2 H2FLB8 P16591

Target Cross References - Domain

InterPro IPR000719 (Prot_kinase_dom.)
IPR000980 (SH2.)
IPR001060 (FCH_dom.)
IPR001245 (Ser-Thr/Tyr_kinase_cat_dom.)
IPR008266 (Tyr_kinase_AS.)
IPR011009 (Kinase-like_dom_sf.)
IPR016250 (Tyr-prot_kinase_Fes/Fps.)
IPR017441 (Protein_kinase_ATP_BS.)
IPR020635 (Tyr_kinase_cat_dom.)
IPR027267 (AH/BAR_dom_sf.)
IPR028539 (Fer.)
IPR031160 (F_BAR.)
IPR035849 (Fes/Fps/Fer_SH2.)
IPR036860 (SH2_dom_sf.)
IPR037452 (Fer_F-BAR.)
Pfam PF00017 (SH2)
PF00611 (FCH)
PF07714 (Pkinase_Tyr)