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ChEMBL

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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL3980
Target Type SINGLE PROTEIN
Preferred Name Serine/threonine-protein kinase 17B
Synonyms DAP kinase-related apoptosis-inducing protein kinase 2 | DRAK2 | STK17B | Serine/threonine-protein kinase 17B
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme > kinase > protein kinase > camk protein kinase group > camk protein kinase dapk family

Target Components

Component Description Relationship Accession
Serine/threonine-protein kinase 17B SINGLE PROTEIN O94768

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000081320
Ensembl ENSG00000081320
GO Cellular Component GO:0005634 (nucleus)
GO:0005793 (endoplasmic reticulum-Golgi intermediate compartment)
GO:0005886 (plasma membrane)
GO:0015629 (actin cytoskeleton)
GO:0016020 (membrane)
GO Molecular Function GO:0000166 (nucleotide binding)
GO:0004672 (protein kinase activity)
GO:0004674 (protein serine/threonine kinase activity)
GO:0005524 (ATP binding)
GO:0016301 (kinase activity)
GO:0016740 (transferase activity)
GO Biological Process GO:0006468 (protein phosphorylation)
GO:0006915 (apoptotic process)
GO:0012501 (programmed cell death)
GO:0016310 (phosphorylation)
GO:0035556 (intracellular signal transduction)
GO:0046777 (protein autophosphorylation)
GO:2000271 (positive regulation of fibroblast apoptotic process)

Target Cross References - Protein

canSAR O94768
Human Protein Atlas ENSG00000081320
IntAct O94768
Guide to Pharmacology 2215
Open Targets ENSG00000081320
PharmGKB PA36204
Pharos O94768 (Tchem)
UniProt O94768

Target Cross References - Domain

InterPro IPR000719 (Prot_kinase_dom.)
IPR008271 (Ser/Thr_kinase_AS.)
IPR011009 (Kinase-like_dom_sf.)
IPR017441 (Protein_kinase_ATP_BS.)
Pfam PF00069 (Pkinase)

Target Cross References - Structure

PDBe 3LM0 3LM5
CREDO 3LM0 3LM5
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