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ChEMBL

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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL3965
Target Type SINGLE PROTEIN
Preferred Name Leucine aminopeptidase
Synonyms Cytosol aminopeptidase | LAP-3 | LAP3 | LAPEP | Leucine aminopeptidase 3 | Leucyl aminopeptidase | PEPS | Peptidase S | Proline aminopeptidase | Prolyl aminopeptidase
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme > protease > metallo protease > metallo protease mf clan > metallo protease m17 family

Target Components

Component Description Relationship Accession
Cytosol aminopeptidase SINGLE PROTEIN P28838

Target Relations

ChEMBL ID Pref Name Target Type
CHEMBL3831223 Aminopeptidase PROTEIN FAMILY

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000002549
Ensembl ENSG00000002549
GO Cellular Component GO:0005622 (intracellular)
GO:0005634 (nucleus)
GO:0005654 (nucleoplasm)
GO:0005737 (cytoplasm)
GO:0005739 (mitochondrion)
GO:0005802 (trans-Golgi network)
GO:0005925 (focal adhesion)
GO:0070062 (extracellular exosome)
GO Molecular Function GO:0004177 (aminopeptidase activity)
GO:0008233 (peptidase activity)
GO:0008235 (metalloexopeptidase activity)
GO:0016787 (hydrolase activity)
GO:0030145 (manganese ion binding)
GO:0046872 (metal ion binding)
GO Biological Process GO:0006508 (proteolysis)
GO:0019538 (protein metabolic process)

Target Cross References - Protein

canSAR P28838
Human Protein Atlas ENSG00000002549
IntAct P28838
Open Targets ENSG00000002549
PharmGKB PA38537
UniProt B3KMQ3 P28838 Q6IAM6 Q6P0L6 Q9UQE3

Target Cross References - Domain

InterPro IPR000819 (Peptidase_M17_C.)
IPR008283 (Peptidase_M17_N.)
IPR011356 (Leucine_aapep/pepB.)
IPR023042 (Peptidase_M17_leu_NH2_pept.)
Pfam PF00883 (Peptidase_M17)
PF02789 (Peptidase_M17_N)
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