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Target Report Card

Target Name and Classification

Target ID CHEMBL3961
Preferred Name MAP kinase p38 beta
Synonyms MAP kinase 11 | MAP kinase p38 beta | MAPK 11 | MAPK11 | Mitogen-activated protein kinase 11 | Mitogen-activated protein kinase p38 beta | PRKM11 | SAPK2 | SAPK2B | SAPK2b | Stress-activated protein kinase 2b | p38-2 | p38b
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme > kinase > protein kinase > cmgc protein kinase group > cmgc protein kinase mapk family > cmgc protein kinase p38 subfamily

Target Components

Component Description Relationship Accession
Mitogen-activated protein kinase 11 SINGLE PROTEIN Q15759

Target Relations

ChEMBL ID Pref Name Target Type

Approved Drugs and Clinical Candidates

ChEMBL ID Name Mechanism of Action Max Phase References
CHEMBL1946170 REGORAFENIB MAP kinase p38 beta inhibitor 4 Expert
CHEMBL1088752 LOSMAPIMOD MAP kinase p38 beta inhibitor 3 PubMed PubMed
CHEMBL190333 RWJ-67657 MAP kinase p38 beta inhibitor 1 PubMed

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000185386
Ensembl ENSG00000185386
GO Cellular Component GO:0005634 (nucleus)
GO:0005654 (nucleoplasm)
GO:0005737 (cytoplasm)
GO:0005829 (cytosol)
GO Molecular Function GO:0000166 (nucleotide binding)
GO:0004672 (protein kinase activity)
GO:0004674 (protein serine/threonine kinase activity)
GO:0004707 (MAP kinase activity)
GO:0005515 (protein binding)
GO:0005524 (ATP binding)
GO:0016301 (kinase activity)
GO:0016740 (transferase activity)
GO Biological Process GO:0000187 (activation of MAPK activity)
GO:0006351 (transcription, DNA-templated)
GO:0006355 (regulation of transcription, DNA-templated)
GO:0006468 (protein phosphorylation)
GO:0007265 (Ras protein signal transduction)
GO:0010628 (positive regulation of gene expression)
GO:0016310 (phosphorylation)
GO:0045648 (positive regulation of erythrocyte differentiation)
GO:0048010 (vascular endothelial growth factor receptor signaling pathway)
GO:0051090 (regulation of sequence-specific DNA binding transcription factor activity)
GO:0051149 (positive regulation of muscle cell differentiation)
GO:0051403 (stress-activated MAPK cascade)
GO:0060043 (regulation of cardiac muscle cell proliferation)
GO:0060044 (negative regulation of cardiac muscle cell proliferation)
GO:0071347 (cellular response to interleukin-1)
GO:0098586 (cellular response to virus)
GO:1901796 (regulation of signal transduction by p53 class mediator)
GO:2001184 (positive regulation of interleukin-12 secretion)
Wikipedia MAPK11

Target Cross References - Protein

canSAR Q15759
Human Protein Atlas ENSG00000185386
IntAct Q15759
Guide to Pharmacology 1500
Open Targets ENSG00000185386
PharmGKB PA30618
Pharos Q15759 (Tchem)
Reactome R-HSA-168638 (NOD1/2 Signaling Pathway.)
R-HSA-171007 (p38MAPK events.)
R-HSA-198753 (ERK/MAPK targets.)
R-HSA-2151209 (Activation of PPARGC1A (PGC-1alpha) by phosphorylation.)
R-HSA-2559580 (Oxidative Stress Induced Senescence.)
R-HSA-375170 (CDO in myogenesis.)
R-HSA-376172 (DSCAM interactions.)
R-HSA-4420097 (VEGFA-VEGFR2 Pathway.)
R-HSA-450302 (activated TAK1 mediates p38 MAPK activation.)
R-HSA-450341 (Activation of the AP-1 family of transcription factors.)
R-HSA-450604 (KSRP (KHSRP) binds and destabilizes mRNA.)
R-HSA-6804756 (Regulation of TP53 Activity through Phosphorylation.)
UniProt A8K730 B0LPG1 B7Z630 E7ETQ1 L7RT27 O00284 O15472 Q15759 Q2XNF2

Target Cross References - Domain

InterPro IPR000719 (Prot_kinase_dom.)
IPR003527 (MAP_kinase_CS.)
IPR008352 (MAPK_p38.)
IPR011009 (Kinase-like_dom_sf.)
IPR017441 (Protein_kinase_ATP_BS.)
Pfam PF00069 (Pkinase)

Target Cross References - Structure

PDBe 3GC8 3GC9 3GP0