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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL3938
Target Type SINGLE PROTEIN
Preferred Name Serine/threonine-protein kinase 16
Synonyms MPSK | MPSK1 | Myristoylated and palmitoylated serine/threonine-protein kinase | PKL12 | Protein kinase PKL12 | STK16 | Serine/threonine-protein kinase 16 | TGF-beta-stimulated factor 1 | TSF-1 | TSF1 | Tyrosine-protein kinase STK16 | hPSK
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme > kinase > protein kinase > other protein kinase group > other protein kinase nak family

Target Components

Component Description Relationship Accession
Serine/threonine-protein kinase 16 SINGLE PROTEIN O75716

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000115661
Ensembl ENSG00000115661
GO Cellular Component GO:0005737 (cytoplasm)
GO:0005798 (Golgi-associated vesicle)
GO:0005829 (cytosol)
GO:0016020 (membrane)
GO:0048471 (perinuclear region of cytoplasm)
GO Molecular Function GO:0000166 (nucleotide binding)
GO:0001077 (transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding)
GO:0004672 (protein kinase activity)
GO:0004674 (protein serine/threonine kinase activity)
GO:0004715 (non-membrane spanning protein tyrosine kinase activity)
GO:0005515 (protein binding)
GO:0005524 (ATP binding)
GO:0016301 (kinase activity)
GO:0016740 (transferase activity)
GO Biological Process GO:0006366 (transcription from RNA polymerase II promoter)
GO:0006468 (protein phosphorylation)
GO:0016310 (phosphorylation)
GO:0018108 (peptidyl-tyrosine phosphorylation)
GO:0045944 (positive regulation of transcription from RNA polymerase II promoter)
GO:0046777 (protein autophosphorylation)
GO:0071560 (cellular response to transforming growth factor beta stimulus)
Wikipedia STK16

Target Cross References - Protein

canSAR O75716
Human Protein Atlas ENSG00000115661
IntAct O75716
Guide to Pharmacology 2213
Open Targets ENSG00000115661
PharmGKB PA36202
Pharos O75716 (Tchem)
UniProt A8K9H9 O75716 Q5U0F8 Q96KI2 Q9BUH4 Q9UEN3 Q9UP78

Target Cross References - Domain

InterPro IPR000719 (Prot_kinase_dom.)
IPR008271 (Ser/Thr_kinase_AS.)
IPR011009 (Kinase-like_dom_sf.)
Pfam PF00069 (Pkinase)

Target Cross References - Structure

PDBe 2BUJ
CREDO 2BUJ
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