ChEMBL logo

ChEMBL

spacer
ChEMBL Statistics
  Loading Statistics...
spacer

Target Report Card

Target Name and Classification

Target ID CHEMBL3935
Target Type SINGLE PROTEIN
Preferred Name Serine/threonine-protein kinase Aurora-C
Synonyms AIE2 | AIK3 | AIRK3 | ARK-3 | ARK3 | AURKC | Aurora 3 | Aurora kinase C | Aurora-related kinase 3 | Aurora/IPL1-related kinase 3 | Aurora/IPL1/Eg2 protein 2 | STK13 | Serine/threonine-protein kinase 13 | Serine/threonine-protein kinase aurora-C
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme > kinase > protein kinase > other protein kinase group > other protein kinase aur family

Target Components

Component Description Relationship Accession
Aurora kinase C SINGLE PROTEIN Q9UQB9

Target Relations

ChEMBL ID Pref Name Target Type
CHEMBL3430911 Serine/threonine-protein kinase Aurora PROTEIN FAMILY

Approved Drugs and Clinical Candidates

ChEMBL ID Name Mechanism of Action Max Phase References
CHEMBL1090479 GSK-1070916 Serine/threonine-protein kinase Aurora-C inhibitor 1 PubMed PubMed

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000105146
Ensembl ENSG00000105146
GO Cellular Component GO:0000775 (chromosome, centromeric region)
GO:0000780 (condensed nuclear chromosome, centromeric region)
GO:0000793 (condensed chromosome)
GO:0005634 (nucleus)
GO:0005694 (chromosome)
GO:0005737 (cytoplasm)
GO:0005819 (spindle)
GO:0005856 (cytoskeleton)
GO:0005876 (spindle microtubule)
GO:0030496 (midbody)
GO:0031616 (spindle pole centrosome)
GO:0032133 (chromosome passenger complex)
GO:0051233 (spindle midzone)
GO Molecular Function GO:0000166 (nucleotide binding)
GO:0004672 (protein kinase activity)
GO:0004674 (protein serine/threonine kinase activity)
GO:0004712 (protein serine/threonine/tyrosine kinase activity)
GO:0005524 (ATP binding)
GO:0016301 (kinase activity)
GO:0016740 (transferase activity)
GO:0035174 (histone serine kinase activity)
GO Biological Process GO:0000910 (cytokinesis)
GO:0006468 (protein phosphorylation)
GO:0007049 (cell cycle)
GO:0007067 (mitotic nuclear division)
GO:0007283 (spermatogenesis)
GO:0008608 (attachment of spindle microtubules to kinetochore)
GO:0016310 (phosphorylation)
GO:0016570 (histone modification)
GO:0032467 (positive regulation of cytokinesis)
GO:0035404 (histone-serine phosphorylation)
GO:0048599 (oocyte development)
GO:0051255 (spindle midzone assembly)
GO:0051256 (mitotic spindle midzone assembly)
GO:0051301 (cell division)
GO:0051321 (meiotic cell cycle)
Wikipedia AURKC

Target Cross References - Protein

canSAR Q9UQB9
CGD Spermatogenic failure 5
Human Protein Atlas ENSG00000105146
IntAct Q9UQB9
Guide to Pharmacology 1938
Open Targets ENSG00000105146
PharmGKB PA36200
Pharos Q9UQB9 (Tchem)
UniProt O60681 O75442 Q6AZY8 Q6DLZ0 Q9UPK5 Q9UQB9

Target Cross References - Domain

InterPro IPR000719 (Prot_kinase_dom.)
IPR008271 (Ser/Thr_kinase_AS.)
IPR011009 (Kinase-like_dom.)
IPR017441 (Protein_kinase_ATP_BS.)
IPR030613 (AURKC.)
IPR030616 (Aur.)
Pfam PF00069 (Pkinase)
spacer
spacer