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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL3922
Target Type SINGLE PROTEIN
Preferred Name Methionine aminopeptidase 2
Synonyms Initiation factor 2-associated 67 kDa glycoprotein | MAP 2 | METAP2 | MNPEP | MetAP 2 | Methionine aminopeptidase 2 | P67EIF2 | Peptidase M | p67 | p67eIF2
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme > protease > metallo protease > metallo protease mg clan > metallo protease m24a subfamily

Target Components

Component Description Relationship Accession
Methionine aminopeptidase 2 SINGLE PROTEIN P50579

Target Relations

ChEMBL ID Pref Name Target Type
CHEMBL3831223 Aminopeptidase PROTEIN FAMILY

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000111142
Ensembl ENSG00000111142
GO Cellular Component GO:0005737 (cytoplasm)
GO:0005829 (cytosol)
GO:0005886 (plasma membrane)
GO Molecular Function GO:0004177 (aminopeptidase activity)
GO:0008233 (peptidase activity)
GO:0008235 (metalloexopeptidase activity)
GO:0016787 (hydrolase activity)
GO:0044822 (poly(A) RNA binding)
GO:0046872 (metal ion binding)
GO:0070006 (metalloaminopeptidase activity)
GO Biological Process GO:0006508 (proteolysis)
GO:0016485 (protein processing)
GO:0018206 (peptidyl-methionine modification)
GO:0022400 (regulation of rhodopsin mediated signaling pathway)
GO:0031365 (N-terminal protein amino acid modification)
GO:0070084 (protein initiator methionine removal)
Wikipedia METAP2

Target Cross References - Protein

canSAR P50579
Human Protein Atlas ENSG00000111142
IntAct P50579
Guide to Pharmacology 1573
Open Targets ENSG00000111142
PharmGKB PA30765
Reactome R-HSA-2514859 (Inactivation, recovery and regulation of the phototransduction cascade.)
UniProt B2RDI8 B4DUX5 G3XA91 P50579 Q8NB11

Target Cross References - Domain

InterPro IPR000994 (Pept_M24.)
IPR001714 (Pept_M24_MAP.)
IPR002468 (Pept_M24A_MAP2.)
IPR011991 (WHTH_DNA-bd_dom.)
IPR018349 (Pept_M24A_MAP2_BS.)
Pfam PF00557 (Peptidase_M24)

Target Cross References - Structure

PDBe 1B59 1B6A 1BN5 1BOA 1KQ0 1KQ9 1QZY 1R58 1R5G 1R5H 1YW7 1YW8 1YW9 2ADU 2EA2 2EA4 2GA2 2OAZ 5CLS 5D6E 5D6F 5JFR 5JHU 5JI6
CREDO 1B59 1B6A 1BN5 1BOA 1KQ0 1KQ9 1QZY 1R58 1R5G 1R5H 1YW7 1YW8 1YW9 2ADU 2EA2 2EA4 2GA2 2OAZ 5CLS 5D6E 5D6F 5JFR 5JHU 5JI6
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