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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL3919
Target Type SINGLE PROTEIN
Preferred Name Potassium-transporting ATPase alpha chain 1
Synonyms ATP4A | Gastric H(+)/K(+) ATPase subunit alpha | Potassium-transporting ATPase alpha chain 1 | Proton pump
Organism Sus scrofa
Species Group No
Protein Target Classification
  • transporter > primary active transporter > p-type atpase > hydrogen potassium atpase
  • enzyme > hydrolase

Target Components

Component Description Relationship Accession
Potassium-transporting ATPase alpha chain 1 SINGLE PROTEIN P19156

Target Relations

ChEMBL ID Pref Name Target Type
CHEMBL2095228 Potassium-transporting ATPase PROTEIN COMPLEX

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

GO Cellular Component GO:0005886 (plasma membrane)
GO:0005887 (integral component of plasma membrane)
GO:0016020 (membrane)
GO:0016021 (integral component of membrane)
GO:0043231 (intracellular membrane-bounded organelle)
GO Molecular Function GO:0000166 (nucleotide binding)
GO:0000287 (magnesium ion binding)
GO:0005391 (sodium:potassium-exchanging ATPase activity)
GO:0005524 (ATP binding)
GO:0008900 (hydrogen:potassium-exchanging ATPase activity)
GO:0016787 (hydrolase activity)
GO:0046872 (metal ion binding)
GO Biological Process GO:0006810 (transport)
GO:0006811 (ion transport)
GO:0006813 (potassium ion transport)
GO:0006814 (sodium ion transport)
GO:0006883 (cellular sodium ion homeostasis)
GO:0010107 (potassium ion import)
GO:0010248 (establishment or maintenance of transmembrane electrochemical gradient)
GO:0015991 (ATP hydrolysis coupled proton transport)
GO:0015992 (proton transport)
GO:0030007 (cellular potassium ion homeostasis)
GO:0036376 (sodium ion export from cell)

Target Cross References - Protein

canSAR P19156
IntAct P19156
UniProt P19156

Target Cross References - Domain

InterPro IPR001757 (P_typ_ATPase.)
IPR004014 (ATPase_P-typ_cation-transptr_N.)
IPR005775 (P-type_ATPase_IIC.)
IPR006068 (ATPase_P-typ_cation-transptr_C.)
IPR008250 (ATPase_P-typ_transduc_dom_A.)
IPR015127 (ATPase_P-typ_H/K-transp_N.)
IPR018303 (ATPase_P-typ_P_site.)
IPR023214 (HAD-like_dom.)
IPR023298 (ATPase_P-typ_TM_dom.)
IPR023299 (ATPase_P-typ_cyto_domN.)
Pfam PF00122 (E1-E2_ATPase)
PF00689 (Cation_ATPase_C)
PF00690 (Cation_ATPase_N)
PF09040 (H-K_ATPase_N)
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