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Target Report Card

Target Name and Classification

Target ID CHEMBL3905
Preferred Name Tyrosine-protein kinase Lyn
Synonyms JTK8 | LYN | Lck/Yes-related novel protein tyrosine kinase | Tyrosine-protein kinase Lyn | V-yes-1 Yamaguchi sarcoma viral related oncogene homolog | p53Lyn | p56Lyn
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme > kinase > protein kinase > tk protein kinase group > tyrosine protein kinase src family

Target Components

Component Description Relationship Accession
Tyrosine-protein kinase Lyn SINGLE PROTEIN P07948

Target Relations

ChEMBL ID Pref Name Target Type

Approved Drugs and Clinical Candidates

ChEMBL ID Name Mechanism of Action Max Phase References
CHEMBL288441 BOSUTINIB Tyrosine-protein kinase Lyn inhibitor 4 Expert
CHEMBL206834 BAFETINIB Tyrosine-protein kinase Lyn inhibitor 2 PubMed
CHEMBL3545133 JNJ-26483327 Tyrosine-protein kinase Lyn inhibitor 1 DOI PubMed

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000254087
Ensembl ENSG00000254087
GO Cellular Component GO:0005634 (nucleus)
GO:0005737 (cytoplasm)
GO:0005758 (mitochondrial intermembrane space)
GO:0005794 (Golgi apparatus)
GO:0005829 (cytosol)
GO:0005886 (plasma membrane)
GO:0005913 (cell-cell adherens junction)
GO:0014069 (postsynaptic density)
GO:0016020 (membrane)
GO:0030061 (mitochondrial crista)
GO:0031234 (extrinsic component of cytoplasmic side of plasma membrane)
GO:0031966 (mitochondrial membrane)
GO:0034666 (integrin alpha2-beta1 complex)
GO:0042629 (mast cell granule)
GO:0043231 (intracellular membrane-bounded organelle)
GO:0045121 (membrane raft)
GO:0048471 (perinuclear region of cytoplasm)
GO:0070062 (extracellular exosome)
GO Molecular Function GO:0000166 (nucleotide binding)
GO:0004672 (protein kinase activity)
GO:0004713 (protein tyrosine kinase activity)
GO:0004715 (non-membrane spanning protein tyrosine kinase activity)
GO:0004716 (receptor signaling protein tyrosine kinase activity)
GO:0005102 (receptor binding)
GO:0005161 (platelet-derived growth factor receptor binding)
GO:0005178 (integrin binding)
GO:0005515 (protein binding)
GO:0005524 (ATP binding)
GO:0016301 (kinase activity)
GO:0016740 (transferase activity)
GO:0017124 (SH3 domain binding)
GO:0019899 (enzyme binding)
GO:0031625 (ubiquitin protein ligase binding)
GO:0043015 (gamma-tubulin binding)
GO:0043208 (glycosphingolipid binding)
GO:0044325 (ion channel binding)
GO:0044877 (macromolecular complex binding)
GO:0046875 (ephrin receptor binding)
GO:0051219 (phosphoprotein binding)
GO:0140031 (phosphorylation-dependent protein binding)
GO Biological Process GO:0001782 (B cell homeostasis)
GO:0001817 (regulation of cytokine production)
GO:0001932 (regulation of protein phosphorylation)
GO:0001933 (negative regulation of protein phosphorylation)
GO:0001934 (positive regulation of protein phosphorylation)
GO:0002223 (stimulatory C-type lectin receptor signaling pathway)
GO:0002250 (adaptive immune response)
GO:0002376 (immune system process)
GO:0002431 (Fc receptor mediated stimulatory signaling pathway)
GO:0002513 (tolerance induction to self antigen)
GO:0002553 (histamine secretion by mast cell)
GO:0002576 (platelet degranulation)
GO:0002762 (negative regulation of myeloid leukocyte differentiation)
GO:0002768 (immune response-regulating cell surface receptor signaling pathway)
GO:0002774 (Fc receptor mediated inhibitory signaling pathway)
GO:0002902 (regulation of B cell apoptotic process)
GO:0006468 (protein phosphorylation)
GO:0006954 (inflammatory response)
GO:0006974 (cellular response to DNA damage stimulus)
GO:0006991 (response to sterol depletion)
GO:0007165 (signal transduction)
GO:0007169 (transmembrane receptor protein tyrosine kinase signaling pathway)
GO:0007417 (central nervous system development)
GO:0007596 (blood coagulation)
GO:0008284 (positive regulation of cell proliferation)
GO:0008285 (negative regulation of cell proliferation)
GO:0009636 (response to toxic substance)
GO:0009725 (response to hormone)
GO:0009743 (response to carbohydrate)
GO:0010976 (positive regulation of neuron projection development)
GO:0014003 (oligodendrocyte development)
GO:0014070 (response to organic cyclic compound)
GO:0016032 (viral process)
GO:0016310 (phosphorylation)
GO:0018108 (peptidyl-tyrosine phosphorylation)
GO:0023014 (signal transduction by protein phosphorylation)
GO:0030097 (hemopoiesis)
GO:0030168 (platelet activation)
GO:0030218 (erythrocyte differentiation)
GO:0030335 (positive regulation of cell migration)
GO:0030889 (negative regulation of B cell proliferation)
GO:0031175 (neuron projection development)
GO:0031295 (T cell costimulation)
GO:0031663 (lipopolysaccharide-mediated signaling pathway)
GO:0031668 (cellular response to extracellular stimulus)
GO:0032868 (response to insulin)
GO:0033003 (regulation of mast cell activation)
GO:0033628 (regulation of cell adhesion mediated by integrin)
GO:0034136 (negative regulation of toll-like receptor 2 signaling pathway)
GO:0034144 (negative regulation of toll-like receptor 4 signaling pathway)
GO:0034605 (cellular response to heat)
GO:0035556 (intracellular signal transduction)
GO:0038083 (peptidyl-tyrosine autophosphorylation)
GO:0038095 (Fc-epsilon receptor signaling pathway)
GO:0038096 (Fc-gamma receptor signaling pathway involved in phagocytosis)
GO:0042327 (positive regulation of phosphorylation)
GO:0042493 (response to drug)
GO:0042531 (positive regulation of tyrosine phosphorylation of STAT protein)
GO:0043200 (response to amino acid)
GO:0043304 (regulation of mast cell degranulation)
GO:0043407 (negative regulation of MAP kinase activity)
GO:0043434 (response to peptide hormone)
GO:0043552 (positive regulation of phosphatidylinositol 3-kinase activity)
GO:0045087 (innate immune response)
GO:0045646 (regulation of erythrocyte differentiation)
GO:0046777 (protein autophosphorylation)
GO:0048013 (ephrin receptor signaling pathway)
GO:0048678 (response to axon injury)
GO:0050663 (cytokine secretion)
GO:0050707 (regulation of cytokine secretion)
GO:0050727 (regulation of inflammatory response)
GO:0050731 (positive regulation of peptidyl-tyrosine phosphorylation)
GO:0050777 (negative regulation of immune response)
GO:0050853 (B cell receptor signaling pathway)
GO:0050855 (regulation of B cell receptor signaling pathway)
GO:0050861 (positive regulation of B cell receptor signaling pathway)
GO:0050900 (leukocyte migration)
GO:0051272 (positive regulation of cellular component movement)
GO:0051279 (regulation of release of sequestered calcium ion into cytosol)
GO:0060252 (positive regulation of glial cell proliferation)
GO:0060369 (positive regulation of Fc receptor mediated stimulatory signaling pathway)
GO:0060397 (JAK-STAT cascade involved in growth hormone signaling pathway)
GO:0070304 (positive regulation of stress-activated protein kinase signaling cascade)
GO:0070372 (regulation of ERK1 and ERK2 cascade)
GO:0070373 (negative regulation of ERK1 and ERK2 cascade)
GO:0070447 (positive regulation of oligodendrocyte progenitor proliferation)
GO:0070667 (negative regulation of mast cell proliferation)
GO:0070668 (positive regulation of mast cell proliferation)
GO:0071300 (cellular response to retinoic acid)
GO:0090025 (regulation of monocyte chemotaxis)
GO:0090330 (regulation of platelet aggregation)
GO:0097028 (dendritic cell differentiation)
GO:1902532 (negative regulation of intracellular signal transduction)
GO:1902961 (positive regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process)
GO:2000670 (positive regulation of dendritic cell apoptotic process)
Wikipedia LYN

Target Cross References - Protein

canSAR P07948
Human Protein Atlas ENSG00000254087
IntAct P07948
Guide to Pharmacology 2060
Open Targets ENSG00000254087
PharmGKB PA30498
Pharos P07948 (Tclin)
Reactome R-HSA-114604 (GPVI-mediated activation cascade.)
R-HSA-1433557 (Signaling by SCF-KIT.)
R-HSA-1433559 (Regulation of KIT signaling.)
R-HSA-202733 (Cell surface interactions at the vascular wall.)
R-HSA-2029481 (FCGR activation.)
R-HSA-210990 (PECAM1 interactions.)
R-HSA-2454202 (Fc epsilon receptor (FCERI) signaling.)
R-HSA-2682334 (EPH-Ephrin signaling.)
R-HSA-2730905 (Role of LAT2/NTAL/LAB on calcium mobilization.)
R-HSA-2871796 (FCERI mediated MAPK activation.)
R-HSA-2871809 (FCERI mediated Ca+2 mobilization.)
R-HSA-2871837 (FCERI mediated NF-kB activation.)
R-HSA-389356 (CD28 co-stimulation.)
R-HSA-389513 (CTLA4 inhibitory signaling.)
R-HSA-3928662 (EPHB-mediated forward signaling.)
R-HSA-3928663 (EPHA-mediated growth cone collapse.)
R-HSA-3928665 (EPH-ephrin mediated repulsion of cells.)
R-HSA-5621480 (Dectin-2 family.)
R-HSA-5621575 (CD209 (DC-SIGN) signaling.)
R-HSA-5690714 (CD22 mediated BCR regulation.)
R-HSA-69231 (Cyclin D associated events in G1.)
R-HSA-75892 (Platelet Adhesion to exposed collagen.)
R-HSA-912631 (Regulation of signaling by CBL.)
R-HSA-982772 (Growth hormone receptor signaling.)
R-HSA-983695 (Antigen activates B Cell Receptor (BCR) leading to generation of second messengers.)
UniProt A0AVQ5 P07948

Target Cross References - Domain

InterPro IPR000719 (Prot_kinase_dom.)
IPR000980 (SH2.)
IPR001245 (Ser-Thr/Tyr_kinase_cat_dom.)
IPR001452 (SH3_domain.)
IPR008266 (Tyr_kinase_AS.)
IPR011009 (Kinase-like_dom_sf.)
IPR017441 (Protein_kinase_ATP_BS.)
IPR020635 (Tyr_kinase_cat_dom.)
IPR035748 (Lyn_SH3.)
IPR035852 (Lyn_SH2.)
IPR036028 (SH3-like_dom_sf.)
IPR036860 (SH2_dom_sf.)
Pfam PF00017 (SH2)
PF00018 (SH3_1)
PF07714 (Pkinase_Tyr)

Target Cross References - Structure

PDBe 3A4O 5XY1