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Target Report Card

Target Name and Classification

Target ID CHEMBL3901
Preferred Name Sarcoplasmic/endoplasmic reticulum calcium ATPase 2
Synonyms ATP2A2 | ATP2B | Calcium pump 2 | Calcium-transporting ATPase sarcoplasmic reticulum type, slow twitch skeletal muscle isoform | Endoplasmic reticulum class 1/2 Ca(2+) ATPase | SERCA2 | SR Ca(2+)-ATPase 2 | Sarcoplasmic/endoplasmic reticulum calcium ATPase 2
Organism Homo sapiens
Species Group No
Protein Target Classification
  • transporter > primary active transporter > p-type atpase > calcium atpase
  • enzyme > hydrolase

Target Components

Component Description Relationship Accession
Sarcoplasmic/endoplasmic reticulum calcium ATPase 2 SINGLE PROTEIN P16615

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000174437
Ensembl ENSG00000174437
GO Cellular Component GO:0005783 (endoplasmic reticulum)
GO:0005789 (endoplasmic reticulum membrane)
GO:0005887 (integral component of plasma membrane)
GO:0012506 (vesicle membrane)
GO:0014704 (intercalated disc)
GO:0014801 (longitudinal sarcoplasmic reticulum)
GO:0016020 (membrane)
GO:0016021 (integral component of membrane)
GO:0016529 (sarcoplasmic reticulum)
GO:0031095 (platelet dense tubular network membrane)
GO:0031234 (extrinsic component of cytoplasmic side of plasma membrane)
GO:0033017 (sarcoplasmic reticulum membrane)
GO:0043234 (protein complex)
GO:0048471 (perinuclear region of cytoplasm)
GO:0090534 (calcium ion-transporting ATPase complex)
GO:0097470 (ribbon synapse)
GO Molecular Function GO:0000166 (nucleotide binding)
GO:0005388 (calcium-transporting ATPase activity)
GO:0005509 (calcium ion binding)
GO:0005515 (protein binding)
GO:0005524 (ATP binding)
GO:0008022 (protein C-terminus binding)
GO:0016787 (hydrolase activity)
GO:0019899 (enzyme binding)
GO:0031775 (lutropin-choriogonadotropic hormone receptor binding)
GO:0044548 (S100 protein binding)
GO:0046872 (metal ion binding)
GO:0086039 (calcium-transporting ATPase activity involved in regulation of cardiac muscle cell membrane potential)
GO Biological Process GO:0002026 (regulation of the force of heart contraction)
GO:0006810 (transport)
GO:0006811 (ion transport)
GO:0006816 (calcium ion transport)
GO:0006874 (cellular calcium ion homeostasis)
GO:0006984 (ER-nucleus signaling pathway)
GO:0006996 (organelle organization)
GO:0007155 (cell adhesion)
GO:0008544 (epidermis development)
GO:0010460 (positive regulation of heart rate)
GO:0010882 (regulation of cardiac muscle contraction by calcium ion signaling)
GO:0014883 (transition between fast and slow fiber)
GO:0032469 (endoplasmic reticulum calcium ion homeostasis)
GO:0032470 (positive regulation of endoplasmic reticulum calcium ion concentration)
GO:0033292 (T-tubule organization)
GO:0034220 (ion transmembrane transport)
GO:0034599 (cellular response to oxidative stress)
GO:0034976 (response to endoplasmic reticulum stress)
GO:0043434 (response to peptide hormone)
GO:0045822 (negative regulation of heart contraction)
GO:0055119 (relaxation of cardiac muscle)
GO:0070296 (sarcoplasmic reticulum calcium ion transport)
GO:0070588 (calcium ion transmembrane transport)
GO:0086036 (regulation of cardiac muscle cell membrane potential)
GO:0098909 (regulation of cardiac muscle cell action potential involved in regulation of contraction)
GO:1903233 (regulation of calcium ion-dependent exocytosis of neurotransmitter)
GO:1903515 (calcium ion transport from cytosol to endoplasmic reticulum)
GO:1903779 (regulation of cardiac conduction)
GO:1990036 (calcium ion import into sarcoplasmic reticulum)

Target Cross References - Protein

canSAR P16615
CGD Darier disease; Acrokeratosis verruciformis (Hopf disease)
Human Protein Atlas ENSG00000174437
IntAct P16615
Open Targets ENSG00000174437
PharmGKB PA71
Reactome R-HSA-1912420 (Pre-NOTCH Processing in Golgi.)
R-HSA-418359 (Reduction of cytosolic Ca++ levels.)
R-HSA-5578775 (Ion homeostasis.)
R-HSA-936837 (Ion transport by P-type ATPases.)
UniProt A6NDN7 B4DF05 P16614 P16615 Q86VJ2

Target Cross References - Domain

InterPro IPR001757 (P_typ_ATPase.)
IPR004014 (ATPase_P-typ_cation-transptr_N.)
IPR005782 (P-type_ATPase_IIA.)
IPR006068 (ATPase_P-typ_cation-transptr_C.)
IPR008250 (ATPase_P-typ_transduc_dom_A.)
IPR018303 (ATPase_P-typ_P_site.)
IPR023214 (HAD-like_dom.)
IPR023298 (ATPase_P-typ_TM_dom.)
IPR023299 (ATPase_P-typ_cyto_domN.)
IPR030327 (SERCA2.)
Pfam PF00122 (E1-E2_ATPase)
PF00689 (Cation_ATPase_C)
PF00690 (Cation_ATPase_N)
PF08282 (Hydrolase_3)