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ChEMBL

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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL3871
Target Type SINGLE PROTEIN
Preferred Name Aldehyde reductase
Synonyms 3-DG-reducing enzyme | Akr1a1 | Alcohol dehydrogenase [NADP(+)] | Aldehyde reductase | Aldo-keto reductase family 1 member A1 | Alr
Organism Rattus norvegicus
Species Group No
Protein Target Classification
  • enzyme

Target Components

Component Description Relationship Accession
Alcohol dehydrogenase [NADP(+)] SINGLE PROTEIN P51635

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

GO Cellular Component GO:0005575 (cellular_component)
GO:0005615 (extracellular space)
GO:0005829 (cytosol)
GO:0016324 (apical plasma membrane)
GO:0070062 (extracellular exosome)
GO Molecular Function GO:0003674 (molecular_function)
GO:0004032 (alditol:NADP+ 1-oxidoreductase activity)
GO:0008106 (alcohol dehydrogenase (NADP+) activity)
GO:0016491 (oxidoreductase activity)
GO:0047939 (L-glucuronate reductase activity)
GO Biological Process GO:0008150 (biological_process)
GO:0019853 (L-ascorbic acid biosynthetic process)
GO:0042840 (D-glucuronate catabolic process)
GO:0046185 (aldehyde catabolic process)
GO:0055114 (oxidation-reduction process)

Target Cross References - Protein

canSAR P51635
Reactome R-RNO-156590 (Glutathione conjugation.)
R-RNO-5661270 (Catabolism of glucuronate to xylulose-5-phosphate.)
UniProt P51635

Target Cross References - Domain

InterPro IPR018170 (Aldo/ket_reductase_CS.)
IPR020471 (Aldo/keto_reductase.)
IPR023210 (NADP_OxRdtase_dom.)
Pfam PF00248 (Aldo_ket_red)
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