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ChEMBL

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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL3830
Target Type SINGLE PROTEIN
Preferred Name Adaptor-associated kinase
Synonyms AAK1 | AP2-associated protein kinase 1 | Adaptor-associated kinase 1 | KIAA1048
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme > kinase > protein kinase > other protein kinase group > other protein kinase nak family

Target Components

Component Description Relationship Accession
AP2-associated protein kinase 1 SINGLE PROTEIN Q2M2I8

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000115977
Ensembl ENSG00000115977
GO Cellular Component GO:0005737 (cytoplasm)
GO:0005886 (plasma membrane)
GO:0005905 (clathrin-coated pit)
GO:0016020 (membrane)
GO:0019897 (extrinsic component of plasma membrane)
GO:0030136 (clathrin-coated vesicle)
GO:0031252 (cell leading edge)
GO:0043195 (terminal bouton)
GO Molecular Function GO:0000166 (nucleotide binding)
GO:0004672 (protein kinase activity)
GO:0004674 (protein serine/threonine kinase activity)
GO:0005112 (Notch binding)
GO:0005515 (protein binding)
GO:0005524 (ATP binding)
GO:0016301 (kinase activity)
GO:0016740 (transferase activity)
GO:0035612 (AP-2 adaptor complex binding)
GO Biological Process GO:0006468 (protein phosphorylation)
GO:0006897 (endocytosis)
GO:0016310 (phosphorylation)
GO:0032880 (regulation of protein localization)
GO:0045747 (positive regulation of Notch signaling pathway)
GO:0046777 (protein autophosphorylation)
GO:0050821 (protein stabilization)
GO:2000369 (regulation of clathrin-mediated endocytosis)
Wikipedia AAK1

Target Cross References - Protein

Human Protein Atlas ENSG00000115977
IntAct Q2M2I8
Guide to Pharmacology 1921
Open Targets ENSG00000115977
PharmGKB PA134990616
Pharos Q2M2I8 (Tchem)
Reactome R-HSA-8856825 (Cargo recognition for clathrin-mediated endocytosis.)
R-HSA-8856828 (Clathrin-mediated endocytosis.)
UniProt Q2M2I8 Q4ZFZ3 Q53RX6 Q9UPV4

Target Cross References - Domain

InterPro IPR000719 (Prot_kinase_dom.)
IPR008271 (Ser/Thr_kinase_AS.)
IPR011009 (Kinase-like_dom.)
Pfam PF00069 (Pkinase)

Target Cross References - Structure

PDBe 4WSQ 5L4Q 5TE0
CREDO 4WSQ 5L4Q 5TE0
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