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Target Report Card

Target Name and Classification

Target ID CHEMBL3820
Target Type SINGLE PROTEIN
Preferred Name Hexokinase type IV
Synonyms GCK | Glucokinase | HK IV | HK4 | Hexokinase type IV | Hexokinase-4 | Hexokinase-D
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme

Target Components

Component Description Relationship Accession
Glucokinase SINGLE PROTEIN P35557

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000106633
Ensembl ENSG00000106633
GO Cellular Component GO:0005654 (nucleoplasm)
GO:0005829 (cytosol)
GO Molecular Function GO:0004340 (glucokinase activity)
GO:0005515 (protein binding)
GO:0005524 (ATP binding)
GO:0005536 (glucose binding)
GO Biological Process GO:0006096 (glycolysis)
GO:0006110 (regulation of glycolysis)
GO:0010827 (regulation of glucose transport)
GO:0015758 (glucose transport)
GO:0031018 (endocrine pancreas development)
GO:0032024 (positive regulation of insulin secretion)
GO:0032869 (cellular response to insulin stimulus)
GO:0042593 (glucose homeostasis)
GO:0044320 (cellular response to leptin stimulus)
GO:0045721 (negative regulation of gluconeogenesis)
GO:0045725 (positive regulation of glycogen biosynthetic process)
GO:0051594 (detection of glucose)
GO:0055085 (transmembrane transport)
Wikipedia Glucokinase

Target Cross References - Protein

canSAR P35557
CGD Diabetes mellitus, permanent neonatal; Hyperinsulinemic hypoglycemia, familial 3
Human Protein Atlas ENSG00000106633
IntAct P35557
Guide to Pharmacology 2798 (Glucokinase)
PharmGKB PA28610
Reactome REACT_13698 (Regulation of beta-cell development.)
REACT_15518 (Transmembrane transport of small molecules.)
REACT_474 (Metabolism of carbohydrates.)
UniProt A4D2J2 A4D2J3 P35557 Q05810

Target Cross References - Domain

InterPro IPR001312 (Hexokinase.)
IPR019807 (Hexokinase_CS.)
IPR022672 (Hexokinase_N.)
IPR022673 (Hexokinase_C.)
Pfam PF00349 (Hexokinase_1)
PF03727 (Hexokinase_2)

Target Cross References - Structure

PDBe 1V4S 1V4T 3A0I 3F9M 3FGU 3FR0 3GOI 3H1V 3ID8 3IDH 3IMX
CREDO 1V4S 1V4T 3A0I 3F9M 3FGU 3FR0 3GOI 3H1V 3ID8 3IDH 3IMX
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