ChEMBL logo

ChEMBL

spacer
ChEMBL Statistics
  Loading Statistics...
spacer

Target Report Card

Target Name and Classification

Target ID CHEMBL3820
Target Type SINGLE PROTEIN
Preferred Name Hexokinase type IV
Synonyms GCK | Glucokinase | HK IV | HK4 | Hexokinase type IV | Hexokinase-4 | Hexokinase-D
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme

Target Components

Component Description Relationship Accession
Glucokinase SINGLE PROTEIN P35557

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000106633
Ensembl ENSG00000106633
GO Cellular Component GO:0005634 (nucleus)
GO:0005654 (nucleoplasm)
GO:0005737 (cytoplasm)
GO:0005739 (mitochondrion)
GO:0005829 (cytosol)
GO:0005884 (actin filament)
GO:0005938 (cell cortex)
GO:0030141 (secretory granule)
GO:0045180 (basal cortex)
GO Molecular Function GO:0000166 (nucleotide binding)
GO:0000287 (magnesium ion binding)
GO:0003824 (catalytic activity)
GO:0004340 (glucokinase activity)
GO:0004396 (hexokinase activity)
GO:0005515 (protein binding)
GO:0005524 (ATP binding)
GO:0005536 (glucose binding)
GO:0008865 (fructokinase activity)
GO:0016301 (kinase activity)
GO:0016740 (transferase activity)
GO:0016773 (phosphotransferase activity, alcohol group as acceptor)
GO:0019158 (mannokinase activity)
GO:0019903 (protein phosphatase binding)
GO:0043531 (ADP binding)
GO Biological Process GO:0001678 (cellular glucose homeostasis)
GO:0005975 (carbohydrate metabolic process)
GO:0005978 (glycogen biosynthetic process)
GO:0006003 (fructose 2,6-bisphosphate metabolic process)
GO:0006006 (glucose metabolic process)
GO:0006096 (glycolytic process)
GO:0006110 (regulation of glycolytic process)
GO:0006739 (NADP metabolic process)
GO:0007204 (positive regulation of cytosolic calcium ion concentration)
GO:0008152 (metabolic process)
GO:0009749 (response to glucose)
GO:0010827 (regulation of glucose transport)
GO:0015758 (glucose transport)
GO:0016310 (phosphorylation)
GO:0019932 (second-messenger-mediated signaling)
GO:0032024 (positive regulation of insulin secretion)
GO:0032811 (negative regulation of epinephrine secretion)
GO:0032869 (cellular response to insulin stimulus)
GO:0042149 (cellular response to glucose starvation)
GO:0042327 (positive regulation of phosphorylation)
GO:0042593 (glucose homeostasis)
GO:0043266 (regulation of potassium ion transport)
GO:0044320 (cellular response to leptin stimulus)
GO:0045721 (negative regulation of gluconeogenesis)
GO:0045725 (positive regulation of glycogen biosynthetic process)
GO:0045821 (positive regulation of glycolytic process)
GO:0046835 (carbohydrate phosphorylation)
GO:0050796 (regulation of insulin secretion)
GO:0051156 (glucose 6-phosphate metabolic process)
GO:0051594 (detection of glucose)
GO:0055088 (lipid homeostasis)
GO:0061621 (canonical glycolysis)
GO:0070509 (calcium ion import)
Wikipedia Glucokinase

Target Cross References - Protein

canSAR P35557
CGD Diabetes mellitus, permanent neonatal; Hyperinsulinemic hypoglycemia, familial 3
Human Protein Atlas ENSG00000106633
IntAct P35557
Guide to Pharmacology 2798
Open Targets ENSG00000106633
PharmGKB PA28610
Pharos P35557 (Tchem)
Reactome R-HSA-170822 (Regulation of Glucokinase by Glucokinase Regulatory Protein.)
R-HSA-210745 (Regulation of gene expression in beta cells.)
R-HSA-5619073 (Defective GCK causes maturity-onset diabetes of the young 2 (MODY2).)
R-HSA-5619107 (Defective TRP may confer susceptibility towards thyroid papillary carcinoma (TPC).)
R-HSA-70153 (Glucose transport.)
R-HSA-70171 (Glycolysis.)
UniProt A4D2J2 A4D2J3 P35557 Q05810

Target Cross References - Domain

InterPro IPR001312 (Hexokinase.)
IPR019807 (Hexokinase_BS.)
IPR022672 (Hexokinase_N.)
IPR022673 (Hexokinase_C.)
Pfam PF00349 (Hexokinase_1)
PF03727 (Hexokinase_2)

Target Cross References - Structure

PDBe 1V4S 1V4T 3A0I 3F9M 3FGU 3FR0 3GOI 3H1V 3ID8 3IDH 3IMX 3QIC 3S41 3VEV 3VEY 3VF6 4DCH 4DHY 4ISE 4ISF 4ISG 4IWV 4IXC 4L3Q More...
CREDO 1V4S 1V4T 3A0I 3F9M 3FGU 3FR0 3GOI 3H1V 3ID8 3IDH 3IMX 3QIC 3S41 3VEV 3VEY 3VF6 4DCH 4DHY 4ISE 4ISF 4ISG 4IWV 4IXC 4L3Q More...
spacer
spacer