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Target Report Card

Target Name and Classification

Target ID CHEMBL3817
Target Type SINGLE PROTEIN
Preferred Name Bcl2-antagonist of cell death (BAD)
Synonyms BAD | BAD | BBC6 | BCL2L8 | Bcl-2-binding component 6 | Bcl-2-like protein 8 | Bcl-xL/Bcl-2-associated death promoter | Bcl2 antagonist of cell death | Bcl2-L-8 | Bcl2-associated agonist of cell death
Organism Homo sapiens
Species Group No
Protein Target Classification
  • other cytosolic protein

Target Components

Component Description Relationship Accession
Bcl2-associated agonist of cell death SINGLE PROTEIN Q92934

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000002330
Ensembl ENSG00000002330
GO Cellular Component GO:0005737 (cytoplasm)
GO:0005739 (mitochondrion)
GO:0005741 (mitochondrial outer membrane)
GO:0005829 (cytosol)
GO:0016020 (membrane)
GO Molecular Function GO:0005515 (protein binding)
GO:0005543 (phospholipid binding)
GO:0008289 (lipid binding)
GO:0008656 (cysteine-type endopeptidase activator activity involved in apoptotic process)
GO:0019901 (protein kinase binding)
GO:0019903 (protein phosphatase binding)
GO:0030346 (protein phosphatase 2B binding)
GO:0043422 (protein kinase B binding)
GO:0046982 (protein heterodimerization activity)
GO:0071889 (14-3-3 protein binding)
GO Biological Process GO:0001666 (response to hypoxia)
GO:0001836 (release of cytochrome c from mitochondria)
GO:0001844 (protein insertion into mitochondrial membrane involved in apoptotic signaling pathway)
GO:0006007 (glucose catabolic process)
GO:0006915 (apoptotic process)
GO:0006919 (activation of cysteine-type endopeptidase activity involved in apoptotic process)
GO:0007283 (spermatogenesis)
GO:0008283 (cell proliferation)
GO:0008625 (extrinsic apoptotic signaling pathway via death domain receptors)
GO:0008630 (intrinsic apoptotic signaling pathway in response to DNA damage)
GO:0009725 (response to hormone)
GO:0009749 (response to glucose)
GO:0010033 (response to organic substance)
GO:0010508 (positive regulation of autophagy)
GO:0010918 (positive regulation of mitochondrial membrane potential)
GO:0014070 (response to organic cyclic compound)
GO:0019050 (suppression by virus of host apoptotic process)
GO:0019221 (cytokine-mediated signaling pathway)
GO:0021987 (cerebral cortex development)
GO:0032024 (positive regulation of insulin secretion)
GO:0032355 (response to estradiol)
GO:0032570 (response to progesterone)
GO:0033133 (positive regulation of glucokinase activity)
GO:0033574 (response to testosterone)
GO:0034201 (response to oleic acid)
GO:0035774 (positive regulation of insulin secretion involved in cellular response to glucose stimulus)
GO:0042493 (response to drug)
GO:0042542 (response to hydrogen peroxide)
GO:0042593 (glucose homeostasis)
GO:0042981 (regulation of apoptotic process)
GO:0043065 (positive regulation of apoptotic process)
GO:0043200 (response to amino acid)
GO:0043280 (positive regulation of cysteine-type endopeptidase activity involved in apoptotic process)
GO:0043281 (regulation of cysteine-type endopeptidase activity involved in apoptotic process)
GO:0044342 (type B pancreatic cell proliferation)
GO:0045471 (response to ethanol)
GO:0045579 (positive regulation of B cell differentiation)
GO:0045582 (positive regulation of T cell differentiation)
GO:0045862 (positive regulation of proteolysis)
GO:0045918 (negative regulation of cytolysis)
GO:0046031 (ADP metabolic process)
GO:0046034 (ATP metabolic process)
GO:0046902 (regulation of mitochondrial membrane permeability)
GO:0046931 (pore complex assembly)
GO:0050679 (positive regulation of epithelial cell proliferation)
GO:0051384 (response to glucocorticoid)
GO:0051592 (response to calcium ion)
GO:0060139 (positive regulation of apoptotic process by virus)
GO:0060154 (cellular process regulating host cell cycle in response to virus)
GO:0071247 (cellular response to chromate)
GO:0071260 (cellular response to mechanical stimulus)
GO:0071316 (cellular response to nicotine)
GO:0071396 (cellular response to lipid)
GO:0071456 (cellular response to hypoxia)
GO:0090200 (positive regulation of release of cytochrome c from mitochondria)
GO:0097190 (apoptotic signaling pathway)
GO:0097191 (extrinsic apoptotic signaling pathway)
GO:0097192 (extrinsic apoptotic signaling pathway in absence of ligand)
GO:0097193 (intrinsic apoptotic signaling pathway)
GO:0097202 (activation of cysteine-type endopeptidase activity)
GO:1900740 (positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway)
GO:1901216 (positive regulation of neuron death)
GO:2000078 (positive regulation of type B pancreatic cell development)
GO:2001244 (positive regulation of intrinsic apoptotic signaling pathway)
Wikipedia Bcl-2-associated_death_promoter

Target Cross References - Protein

canSAR Q92934
Human Protein Atlas ENSG00000002330
IntAct Q92934
Open Targets ENSG00000002330
PharmGKB PA25236
Reactome R-HSA-111447 (Activation of BAD and translocation to mitochondria.)
R-HSA-111453 (BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members.)
R-HSA-193648 (NRAGE signals death through JNK.)
R-HSA-198323 (AKT phosphorylates targets in the cytosol.)
R-HSA-5674400 (Constitutive Signaling by AKT1 E17K in Cancer.)
TIMBAL Bcl-XL%20and%20Bcl-2
UniProt O14803 Q6FH21 Q92934

Target Cross References - Domain

InterPro IPR018868 (BAD.)
Pfam PF10514 (Bcl-2_BAD)
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