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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL3805
Preferred Name Voltage-gated L-type calcium channel alpha-1S subunit
Synonyms CACN1 | CACNA1S | CACNL1A3 {ECO:0000303|PubMed:7713519 | Calcium channel, L type, alpha-1 polypeptide, isoform 3, skeletal muscle | Synonyms=CACH1 | Voltage-dependent L-type calcium channel subunit alpha-1S | Voltage-gated calcium channel subunit alpha Cav1.1
Organism Homo sapiens
Species Group No
Protein Target Classification
  • ion channel > voltage-gated ion channel > voltage-gated calcium channel

Target Components

Component Description Relationship Accession
Voltage-dependent L-type calcium channel subunit alpha-1S SINGLE PROTEIN Q13698

Target Relations

ChEMBL ID Pref Name Target Type
CHEMBL2095229 Voltage-gated L-type calcium channel PROTEIN FAMILY
CHEMBL2363032 Voltage-gated calcium channel PROTEIN COMPLEX GROUP

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000081248
Ensembl ENSG00000081248
GO Cellular Component GO:0005737 (cytoplasm)
GO:0005886 (plasma membrane)
GO:0005891 (voltage-gated calcium channel complex)
GO:0016020 (membrane)
GO:0016021 (integral component of membrane)
GO:0030315 (T-tubule)
GO:0031674 (I band)
GO:0042383 (sarcolemma)
GO:1990454 (L-type voltage-gated calcium channel complex)
GO Molecular Function GO:0005216 (ion channel activity)
GO:0005244 (voltage-gated ion channel activity)
GO:0005245 (voltage-gated calcium channel activity)
GO:0005262 (calcium channel activity)
GO:0005515 (protein binding)
GO:0005516 (calmodulin binding)
GO:0008331 (high voltage-gated calcium channel activity)
GO:0046872 (metal ion binding)
GO Biological Process GO:0006811 (ion transport)
GO:0006816 (calcium ion transport)
GO:0006936 (muscle contraction)
GO:0034765 (regulation of ion transmembrane transport)
GO:0055085 (transmembrane transport)
GO:0061337 (cardiac conduction)
GO:0070588 (calcium ion transmembrane transport)
GO:0071313 (cellular response to caffeine)
GO:0086010 (membrane depolarization during action potential)
Wikipedia Cav1.1

Target Cross References - Protein

canSAR Q13698
CGD Malignant hyperthermia susceptibility 5; Thyrotoxic period paralysis, susceptibility 1; Hypokalemic periodic paralysis, type 1
Human Protein Atlas ENSG00000081248
IntAct Q13698
Guide to Pharmacology 528
Open Targets ENSG00000081248
PharmGKB PA85
Pharos Q13698 (Tchem)
Reactome R-HSA-419037 (NCAM1 interactions.)
R-HSA-5576892 (Phase 0 - rapid depolarisation.)
R-HSA-5576893 (Phase 2 - plateau phase.)
UniProt A4IF51 B1ALM2 Q12896 Q13698 Q13934

Target Cross References - Domain

InterPro IPR002077 (VDCCAlpha1.)
IPR005446 (VDCC_L_a1su.)
IPR005450 (VDCC_L_a1ssu.)
IPR005821 (Ion_trans_dom.)
IPR014873 (VDCC_a1su_IQ.)
IPR027359 (Volt_channel_dom_sf.)
IPR031649 (GPHH_dom.)
Pfam PF00520 (Ion_trans)
PF08763 (Ca_chan_IQ)
PF16905 (GPHH)

Target Cross References - Structure

PDBe 2VAY 6B27