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Target Report Card

Target Name and Classification

Target ID CHEMBL3785
Preferred Name Hydroxycarboxylic acid receptor 2
Synonyms G-protein coupled receptor 109A | G-protein coupled receptor HM74A | GPR109A | HCA2 | HCAR2 | HM74A | Hydroxycarboxylic acid receptor 2 | NIACR1 | Niacin receptor 1 | Nicotinic acid receptor
Organism Homo sapiens
Species Group No
Protein Target Classification
  • membrane receptor > family a g protein-coupled receptor > small molecule receptor (family a gpcr) > carboxylic acid receptor > hydroxycarboxylic acid receptor

Target Components

Component Description Relationship Accession
Hydroxycarboxylic acid receptor 2 SINGLE PROTEIN Q8TDS4

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000182782
Ensembl ENSG00000182782
GO Cellular Component GO:0005886 (plasma membrane)
GO:0016020 (membrane)
GO:0016021 (integral component of membrane)
GO:0030054 (cell junction)
GO Molecular Function GO:0004871 (signal transducer activity)
GO:0004930 (G-protein coupled receptor activity)
GO:0070553 (nicotinic acid receptor activity)
GO Biological Process GO:0001781 (neutrophil apoptotic process)
GO:0006915 (apoptotic process)
GO:0007165 (signal transduction)
GO:0007186 (G-protein coupled receptor signaling pathway)
GO:0033031 (positive regulation of neutrophil apoptotic process)
GO:0050995 (negative regulation of lipid catabolic process)
GO:0070165 (positive regulation of adiponectin secretion)
Wikipedia Niacin_receptor_1

Target Cross References - Protein

Human Protein Atlas ENSG00000182782
Guide to Pharmacology 312
Open Targets ENSG00000182782
PharmGKB PA165961843
Pharos Q8TDS4 (Tclin)
Reactome R-HSA-3296197 (Hydroxycarboxylic acid-binding receptors.)
R-HSA-373076 (Class A/1 (Rhodopsin-like receptors).)
R-HSA-418594 (G alpha (i) signalling events.)
UniProt A0PJL5 A7LGG3 Q8TDS4

Target Cross References - Domain

InterPro IPR000276 (GPCR_Rhodpsn.)
IPR017452 (GPCR_Rhodpsn_7TM.)
IPR028017 (HCAR2/3_rcpt.)
Pfam PF00001 (7tm_1)