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Target Report Card

Target Name and Classification

Target ID CHEMBL3778
Preferred Name Interleukin-1 receptor-associated kinase 4
Synonyms IRAK-4 | IRAK4 | Interleukin-1 receptor-associated kinase 4 | Renal carcinoma antigen NY-REN-64
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme > kinase > protein kinase > tkl protein kinase group > tkl protein kinase irak family

Target Components

Component Description Relationship Accession
Interleukin-1 receptor-associated kinase 4 SINGLE PROTEIN Q9NWZ3

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000198001
Ensembl ENSG00000198001
GO Cellular Component GO:0005615 (extracellular space)
GO:0005634 (nucleus)
GO:0005737 (cytoplasm)
GO:0005829 (cytosol)
GO:0005886 (plasma membrane)
GO:0010008 (endosome membrane)
GO Molecular Function GO:0000166 (nucleotide binding)
GO:0000287 (magnesium ion binding)
GO:0004672 (protein kinase activity)
GO:0004674 (protein serine/threonine kinase activity)
GO:0005149 (interleukin-1 receptor binding)
GO:0005515 (protein binding)
GO:0005524 (ATP binding)
GO:0016301 (kinase activity)
GO:0016740 (transferase activity)
GO Biological Process GO:0001816 (cytokine production)
GO:0002224 (toll-like receptor signaling pathway)
GO:0002376 (immune system process)
GO:0002446 (neutrophil mediated immunity)
GO:0002755 (MyD88-dependent toll-like receptor signaling pathway)
GO:0006468 (protein phosphorylation)
GO:0007165 (signal transduction)
GO:0007254 (JNK cascade)
GO:0016310 (phosphorylation)
GO:0019221 (cytokine-mediated signaling pathway)
GO:0034162 (toll-like receptor 9 signaling pathway)
GO:0043123 (positive regulation of I-kappaB kinase/NF-kappaB signaling)
GO:0045087 (innate immune response)
GO:0048661 (positive regulation of smooth muscle cell proliferation)
GO:0051092 (positive regulation of NF-kappaB transcription factor activity)
GO:0070498 (interleukin-1-mediated signaling pathway)
GO:1990266 (neutrophil migration)

Target Cross References - Protein

CGD IRAK4 deficiency; Invasive pneumococcal disease, recurrent, isolated, 1
Human Protein Atlas ENSG00000198001
IntAct Q9NWZ3
Guide to Pharmacology 2045
Open Targets ENSG00000198001
PharmGKB PA134914577
Pharos Q9NWZ3 (Tchem)
Reactome R-HSA-1257604 (PIP3 activates AKT signaling.)
R-HSA-166058 (MyD88:Mal cascade initiated on plasma membrane.)
R-HSA-5602498 (MyD88 deficiency (TLR2/4).)
R-HSA-5602680 (MyD88 deficiency (TLR5).)
R-HSA-5603037 (IRAK4 deficiency (TLR5).)
R-HSA-5603041 (IRAK4 deficiency (TLR2/4).)
R-HSA-6811558 (PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling.)
R-HSA-9020702 (Interleukin-1 signaling.)
R-HSA-975110 (TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling.)
R-HSA-975138 (TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation.)
R-HSA-975155 (MyD88 dependent cascade initiated on endosome.)
R-HSA-975871 (MyD88 cascade initiated on plasma membrane.)
UniProt Q69FE1 Q8TDF7 Q9NWZ3 Q9Y589

Target Cross References - Domain

InterPro IPR000719 (Prot_kinase_dom.)
IPR001245 (Ser-Thr/Tyr_kinase_cat_dom.)
IPR011009 (Kinase-like_dom_sf.)
IPR011029 (DEATH-like_dom_sf.)
IPR017428 (IRAK4.)
IPR037970 (IRAK4_Death.)
Pfam PF07714 (Pkinase_Tyr)

Target Cross References - Structure

PDBe 2NRU 2NRY 2O8Y 2OIB 2OIC 2OID 3MOP 4RMZ 4U97 4U9A 4XS2 4Y73 4YO6 4YP8 4ZTL 4ZTM 4ZTN 5K72 5K75 5K76 5K7G 5K7I 5KX7 5KX8 More...
CREDO 2NRU 2NRY 2O8Y 2OIB 2OIC 2OID 3MOP 4RMZ 4U97 4U9A 4XS2 4Y73 4YO6 4YP8 4ZTL 4ZTM 4ZTN 5K72 5K75 5K76 5K7G 5K7I 5KX7 5KX8 More...