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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL3774
Target Type SINGLE PROTEIN
Preferred Name Phosphodiesterase 1A
Synonyms 61 kDa Cam-PDE | Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A | Cam-PDE 1A | PDE1A
Organism Bos taurus
Species Group No
Protein Target Classification
  • enzyme > phosphodiesterase > phosphodiesterase 1 > phosphodiesterase 1a

Target Components

Component Description Relationship Accession
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A SINGLE PROTEIN P14100

Target Relations

ChEMBL ID Pref Name Target Type
CHEMBL2111408 Heart phosphodiesterase PROTEIN FAMILY
CHEMBL2097166 Phosphodiesterase 1 PROTEIN FAMILY

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

GO Molecular Function GO:0004114 (3',5'-cyclic-nucleotide phosphodiesterase activity)
GO:0004117 (calmodulin-dependent cyclic-nucleotide phosphodiesterase activity)
GO:0005515 (protein binding)
GO:0005516 (calmodulin binding)
GO:0008081 (phosphoric diester hydrolase activity)
GO:0016787 (hydrolase activity)
GO:0046872 (metal ion binding)
GO:0048101 (calcium- and calmodulin-regulated 3',5'-cyclic-GMP phosphodiesterase activity)
GO Biological Process GO:0007165 (signal transduction)

Target Cross References - Protein

canSAR P14100
IntAct P14100
Reactome R-BTA-111957 (Cam-PDE 1 activation.)
R-BTA-418457 (cGMP effects.)
R-BTA-418555 (G alpha (s) signalling events.)
UniProt P14100 Q08E30 Q28063

Target Cross References - Domain

InterPro IPR002073 (PDEase_catalytic_dom.)
IPR003607 (HD/PDEase_dom.)
IPR013706 (PDEase_N.)
IPR023088 (PDEase.)
IPR023174 (PDEase_CS.)
IPR036971 (PDEase_catalytic_dom_sf.)
Pfam PF00233 (PDEase_I)
PF08499 (PDEase_I_N)
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