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Target Report Card

Target Name and Classification

Target ID CHEMBL3772
Preferred Name Metabotropic glutamate receptor 1
Synonyms GPRC1A | GRM1 | MGLUR1 | Metabotropic glutamate receptor 1 | mGluR1
Organism Homo sapiens
Species Group No
Protein Target Classification
  • membrane receptor > family c g protein-coupled receptor > small molecule receptor (family c gpcr) > neurotransmitter receptor (family c gpcr) > metabotropic glutamate receptor

Target Components

Component Description Relationship Accession
Metabotropic glutamate receptor 1 SINGLE PROTEIN Q13255

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000152822
Ensembl ENSG00000152822
GO Cellular Component GO:0005634 (nucleus)
GO:0005886 (plasma membrane)
GO:0005887 (integral component of plasma membrane)
GO:0014069 (postsynaptic density)
GO:0016020 (membrane)
GO:0016021 (integral component of membrane)
GO:0030425 (dendrite)
GO:0038037 (G-protein coupled receptor dimeric complex)
GO:0038038 (G-protein coupled receptor homodimeric complex)
GO:0042734 (presynaptic membrane)
GO:0043005 (neuron projection)
GO Molecular Function GO:0004871 (signal transducer activity)
GO:0004930 (G-protein coupled receptor activity)
GO:0005515 (protein binding)
GO:0008066 (glutamate receptor activity)
GO:0042802 (identical protein binding)
GO:0099583 (neurotransmitter receptor activity involved in regulation of postsynaptic cytosolic calcium ion concentration)
GO Biological Process GO:0000186 (activation of MAPKK activity)
GO:0000187 (activation of MAPK activity)
GO:0007165 (signal transduction)
GO:0007186 (G-protein coupled receptor signaling pathway)
GO:0007196 (adenylate cyclase-inhibiting G-protein coupled glutamate receptor signaling pathway)
GO:0007216 (G-protein coupled glutamate receptor signaling pathway)
GO:0007268 (chemical synaptic transmission)
GO:0007626 (locomotory behavior)
GO:0019233 (sensory perception of pain)
GO:0038042 (dimeric G-protein coupled receptor signaling pathway)
GO:0043408 (regulation of MAPK cascade)
GO:0051482 (positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway)
GO:0051930 (regulation of sensory perception of pain)
GO:0051966 (regulation of synaptic transmission, glutamatergic)
GO:0071257 (cellular response to electrical stimulus)
GO:0099566 (regulation of postsynaptic cytosolic calcium ion concentration)
Wikipedia Metabotropic_glutamate_receptor_1

Target Cross References - Protein

CGD Spinocerebellar ataxia, autosomal recessive 13
Human Protein Atlas ENSG00000152822
IntAct Q13255
Guide to Pharmacology 289
Open Targets ENSG00000152822
PharmGKB PA28990
Pharos Q13255 (Tchem)
Reactome R-HSA-416476 (G alpha (q) signalling events.)
R-HSA-420499 (Class C/3 (Metabotropic glutamate/pheromone receptors).)
R-HSA-6794361 (Neurexins and neuroligins.)
UniProt B9EG79 F8W805 Q13255 Q13256 Q14757 Q14758 Q5VTF7 Q5VTF8 Q9NU10 Q9UGS9 Q9UGT0

Target Cross References - Domain

InterPro IPR000162 (GPCR_3_mtglu_rcpt.)
IPR000337 (GPCR_3.)
IPR001256 (GPCR_3_mtglu_rcpt_1.)
IPR001828 (ANF_lig-bd_rcpt.)
IPR011500 (GPCR_3_9-Cys_dom.)
IPR017978 (GPCR_3_C.)
IPR017979 (GPCR_3_CS.)
IPR019588 (Metabotropic_Glu_rcpt_Homer-bd.)
IPR028082 (Peripla_BP_I.)
Pfam PF00003 (7tm_3)
PF01094 (ANF_receptor)
PF07562 (NCD3G)
PF10606 (GluR_Homer-bdg)

Target Cross References - Structure

PDBe 3KS9 4OR2