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Target Report Card

Target Name and Classification

Target ID CHEMBL3760
Preferred Name Adenylate cyclase type II
Synonyms ADCY2 | ATP pyrophosphate-lyase 2 | Adenylate cyclase type 2 | Adenylate cyclase type II | Adenylyl cyclase 2 | KIAA1060
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme

Target Components

Component Description Relationship Accession
Adenylate cyclase type 2 SINGLE PROTEIN Q08462

Target Relations

ChEMBL ID Pref Name Target Type
CHEMBL2097167 Adenylate cyclase PROTEIN FAMILY

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000078295
Ensembl ENSG00000078295
GO Cellular Component GO:0005622 (intracellular)
GO:0005737 (cytoplasm)
GO:0005886 (plasma membrane)
GO:0005887 (integral component of plasma membrane)
GO:0008074 (guanylate cyclase complex, soluble)
GO:0016020 (membrane)
GO:0016021 (integral component of membrane)
GO:0030425 (dendrite)
GO:0045121 (membrane raft)
GO Molecular Function GO:0000166 (nucleotide binding)
GO:0000287 (magnesium ion binding)
GO:0004016 (adenylate cyclase activity)
GO:0004383 (guanylate cyclase activity)
GO:0005524 (ATP binding)
GO:0008179 (adenylate cyclase binding)
GO:0016829 (lyase activity)
GO:0016849 (phosphorus-oxygen lyase activity)
GO:0030145 (manganese ion binding)
GO:0046872 (metal ion binding)
GO:0046982 (protein heterodimerization activity)
GO Biological Process GO:0003091 (renal water homeostasis)
GO:0006171 (cAMP biosynthetic process)
GO:0006182 (cGMP biosynthetic process)
GO:0007165 (signal transduction)
GO:0007186 (G-protein coupled receptor signaling pathway)
GO:0007188 (adenylate cyclase-modulating G-protein coupled receptor signaling pathway)
GO:0007189 (adenylate cyclase-activating G-protein coupled receptor signaling pathway)
GO:0007190 (activation of adenylate cyclase activity)
GO:0007193 (adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway)
GO:0009190 (cyclic nucleotide biosynthetic process)
GO:0019933 (cAMP-mediated signaling)
GO:0034199 (activation of protein kinase A activity)
GO:0035556 (intracellular signal transduction)
GO:0071377 (cellular response to glucagon stimulus)
GO:1904322 (cellular response to forskolin)
Wikipedia ADCY2

Target Cross References - Protein

canSAR Q08462
Human Protein Atlas ENSG00000078295
IntAct Q08462
Open Targets ENSG00000078295
PharmGKB PA24561
Reactome R-HSA-163359 (Glucagon signaling in metabolic regulation.)
R-HSA-163615 (PKA activation.)
R-HSA-164378 (PKA activation in glucagon signalling.)
R-HSA-170660 (Adenylate cyclase activating pathway.)
R-HSA-170670 (Adenylate cyclase inhibitory pathway.)
R-HSA-418555 (G alpha (s) signalling events.)
R-HSA-418594 (G alpha (i) signalling events.)
R-HSA-418597 (G alpha (z) signalling events.)
R-HSA-432040 (Vasopressin regulates renal water homeostasis via Aquaporins.)
R-HSA-5610787 (Hedgehog 'off' state.)
TIMBAL Adenylyl%20Cyclase
UniProt B7Z2C1 Q08462 Q2NKL8 Q9UDB2 Q9UPU2

Target Cross References - Domain

InterPro IPR001054 (A/G_cyclase.)
IPR009398 (Adcy_conserved_dom.)
IPR018297 (A/G_cyclase_CS.)
IPR029787 (Nucleotide_cyclase.)
IPR030672 (Adcy.)
IPR032628 (AC_N.)
Pfam PF00211 (Guanylate_cyc)
PF06327 (DUF1053)
PF16214 (AC_N)