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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL3759
Preferred Name Histamine H4 receptor
Synonyms AXOR35 | G-protein coupled receptor 105 | GPCR105 | GPRv53 | H4R | HH4R | HRH4 | Histamine H4 receptor | Pfi-013 | SP9144
Organism Homo sapiens
Species Group No
Protein Target Classification
  • membrane receptor > family a g protein-coupled receptor > small molecule receptor (family a gpcr) > monoamine receptor > histamine receptor

Target Components

Component Description Relationship Accession
Histamine H4 receptor SINGLE PROTEIN Q9H3N8

Target Relations

ChEMBL ID Pref Name Target Type
CHEMBL2111378 Histamine receptor (H3 and H4) SELECTIVITY GROUP

Approved Drugs and Clinical Candidates

ChEMBL ID Name Mechanism of Action Max Phase References
CHEMBL1915540 PF-03893787 Histamine H4 receptor antagonist 2 PubMed
CHEMBL3301609 TOREFORANT Histamine H4 receptor antagonist 2 PubMed
CHEMBL3545345 UR-63325 Histamine H4 receptor antagonist 2 Other PubMed

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000134489
Ensembl ENSG00000134489
GO Cellular Component GO:0005886 (plasma membrane)
GO:0016020 (membrane)
GO:0016021 (integral component of membrane)
GO Molecular Function GO:0004871 (signal transducer activity)
GO:0004930 (G-protein coupled receptor activity)
GO:0004969 (histamine receptor activity)
GO Biological Process GO:0006954 (inflammatory response)
GO:0007165 (signal transduction)
GO:0007186 (G-protein coupled receptor signaling pathway)
GO:0007194 (negative regulation of adenylate cyclase activity)
GO:0007204 (positive regulation of cytosolic calcium ion concentration)
GO:0008150 (biological_process)
GO:0043408 (regulation of MAPK cascade)
Wikipedia Histamine_H4_receptor

Target Cross References - Protein

canSAR Q9H3N8
Human Protein Atlas ENSG00000134489
Guide to Pharmacology 265
Open Targets ENSG00000134489
PharmGKB PA134982275
Pharos Q9H3N8 (Tchem)
Reactome R-HSA-390650 (Histamine receptors.)
R-HSA-418594 (G alpha (i) signalling events.)
UniProt B0YJ19 B2KJ48 Q4G0I6 Q9GZQ0 Q9H3N8

Target Cross References - Domain

InterPro IPR000276 (GPCR_Rhodpsn.)
IPR008102 (Histamine_H4_rcpt.)
IPR017452 (GPCR_Rhodpsn_7TM.)
Pfam PF00001 (7tm_1)