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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL3754
Target Type SINGLE PROTEIN
Preferred Name Beta-2 adrenergic receptor
Synonyms Adrb2 | Adrb2r | Beta-2 adrenergic receptor | Beta-2 adrenoceptor | Beta-2 adrenoreceptor
Organism Rattus norvegicus
Species Group No
Protein Target Classification
  • membrane receptor > family a g protein-coupled receptor > small molecule receptor (family a gpcr) > monoamine receptor > adrenergic receptor

Target Components

Component Description Relationship Accession
Beta-2 adrenergic receptor SINGLE PROTEIN P10608

Target Relations

ChEMBL ID Pref Name Target Type
CHEMBL2095166 Adrenergic receptor beta PROTEIN FAMILY

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

GO Cellular Component GO:0005634 (nucleus)
GO:0005737 (cytoplasm)
GO:0005768 (endosome)
GO:0005769 (early endosome)
GO:0005886 (plasma membrane)
GO:0005887 (integral component of plasma membrane)
GO:0005901 (caveola)
GO:0016020 (membrane)
GO:0016021 (integral component of membrane)
GO:0030424 (axon)
GO:0030425 (dendrite)
GO:0032809 (neuronal cell body membrane)
GO:0042383 (sarcolemma)
GO:0043197 (dendritic spine)
GO:0043231 (intracellular membrane-bounded organelle)
GO Molecular Function GO:0001965 (G-protein alpha-subunit binding)
GO:0004871 (signal transducer activity)
GO:0004930 (G-protein coupled receptor activity)
GO:0004935 (adrenergic receptor activity)
GO:0004941 (beta2-adrenergic receptor activity)
GO:0005515 (protein binding)
GO:0008144 (drug binding)
GO:0030165 (PDZ domain binding)
GO:0031713 (B2 bradykinin receptor binding)
GO:0032403 (protein complex binding)
GO:0035240 (dopamine binding)
GO:0035255 (ionotropic glutamate receptor binding)
GO:0051379 (epinephrine binding)
GO:0051380 (norepinephrine binding)
GO Biological Process GO:0001666 (response to hypoxia)
GO:0001889 (liver development)
GO:0002025 (vasodilation by norepinephrine-epinephrine involved in regulation of systemic arterial blood pressure)
GO:0002086 (diaphragm contraction)
GO:0003059 (positive regulation of the force of heart contraction by epinephrine)
GO:0006940 (regulation of smooth muscle contraction)
GO:0007165 (signal transduction)
GO:0007186 (G-protein coupled receptor signaling pathway)
GO:0007189 (adenylate cyclase-activating G-protein coupled receptor signaling pathway)
GO:0007565 (female pregnancy)
GO:0007568 (aging)
GO:0008284 (positive regulation of cell proliferation)
GO:0008306 (associative learning)
GO:0010765 (positive regulation of sodium ion transport)
GO:0016525 (negative regulation of angiogenesis)
GO:0030279 (negative regulation of ossification)
GO:0032570 (response to progesterone)
GO:0032781 (positive regulation of ATPase activity)
GO:0033574 (response to testosterone)
GO:0035249 (synaptic transmission, glutamatergic)
GO:0035811 (negative regulation of urine volume)
GO:0042060 (wound healing)
GO:0042312 (regulation of vasodilation)
GO:0043065 (positive regulation of apoptotic process)
GO:0043268 (positive regulation of potassium ion transport)
GO:0043627 (response to estrogen)
GO:0044849 (estrous cycle)
GO:0045823 (positive regulation of heart contraction)
GO:0045909 (positive regulation of vasodilation)
GO:0045986 (negative regulation of smooth muscle contraction)
GO:0048633 (positive regulation of skeletal muscle tissue growth)
GO:0050728 (negative regulation of inflammatory response)
GO:0051924 (regulation of calcium ion transport)
GO:0051930 (regulation of sensory perception of pain)
GO:0060079 (excitatory postsynaptic potential)
GO:0071456 (cellular response to hypoxia)
GO:0071548 (response to dexamethasone)
GO:0071867 (response to monoamine)
GO:0071880 (adenylate cyclase-activating adrenergic receptor signaling pathway)
GO:0090331 (negative regulation of platelet aggregation)
GO:0097421 (liver regeneration)
GO:1901098 (positive regulation of autophagosome maturation)
GO:1904504 (positive regulation of lipophagy)

Target Cross References - Protein

canSAR P10608
IntAct P10608
UniProt P10608 Q6LCR3

Target Cross References - Domain

InterPro IPR000276 (GPCR_Rhodpsn.)
IPR000332 (ADRB2_rcpt.)
IPR002233 (ADR_fam.)
IPR017452 (GPCR_Rhodpsn_7TM.)
Pfam PF00001 (7tm_1)
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