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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL3744
Preferred Name Glutamate receptor ionotropic kainate 3
Synonyms GluK3 | GluR-7 | GluR7 | Glur7 | Glutamate receptor 7 | Glutamate receptor ionotropic, kainate 3 | Grik3
Organism Rattus norvegicus
Species Group No
Protein Target Classification
  • ion channel > ligand-gated ion channel > ionotropic glutamate receptor > kainate receptor

Target Components

Component Description Relationship Accession
Glutamate receptor ionotropic, kainate 3 SINGLE PROTEIN P42264

Target Relations

ChEMBL ID Pref Name Target Type
CHEMBL2094119 Glutamate receptor ionotropic, kainate PROTEIN COMPLEX GROUP

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

GO Cellular Component GO:0005886 (plasma membrane)
GO:0016020 (membrane)
GO:0016021 (integral component of membrane)
GO:0030054 (cell junction)
GO:0030424 (axon)
GO:0030425 (dendrite)
GO:0032839 (dendrite cytoplasm)
GO:0043195 (terminal bouton)
GO:0043204 (perikaryon)
GO:0045202 (synapse)
GO:0045211 (postsynaptic membrane)
GO Molecular Function GO:0004970 (ionotropic glutamate receptor activity)
GO:0005216 (ion channel activity)
GO:0005234 (extracellular-glutamate-gated ion channel activity)
GO:0008066 (glutamate receptor activity)
GO:0038023 (signaling receptor activity)
GO Biological Process GO:0006811 (ion transport)
GO:0007165 (signal transduction)
GO:0007268 (chemical synaptic transmission)
GO:0034220 (ion transmembrane transport)
GO:0035235 (ionotropic glutamate receptor signaling pathway)
GO:0042391 (regulation of membrane potential)
GO:0051967 (negative regulation of synaptic transmission, glutamatergic)
GO:0060079 (excitatory postsynaptic potential)

Target Cross References - Protein

canSAR P42264
Guide to Pharmacology 452
UniProt O35420 P42264

Target Cross References - Domain

InterPro IPR001320 (Iontro_rcpt.)
IPR001508 (Iono_rcpt_met.)
IPR001828 (ANF_lig-bd_rcpt.)
IPR019594 (Glu/Gly-bd.)
IPR028082 (Peripla_BP_I.)
Pfam PF00060 (Lig_chan)
PF01094 (ANF_receptor)
PF10613 (Lig_chan-Glu_bd)

Target Cross References - Structure

PDBe 3OLZ 3S9E 3U92 3U93 3U94 4E0W 4G8N 4IGR 4MH5 4NWC 4NWD 5NF6 5O4F
CREDO 3OLZ 3S9E 3U92 3U93 3U94 4E0W 4G8N 4IGR 4MH5 4NWC 4NWD 5NF6 5O4F