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ChEMBL

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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL3737
Target Type SINGLE PROTEIN
Preferred Name Serotonin 1a (5-HT1a) receptor
Synonyms 5-HT-1A | 5-HT1A | 5-hydroxytryptamine receptor 1A | Gpcr18 | Htr1a | Serotonin receptor 1A
Organism Mus musculus
Species Group No
Protein Target Classification
  • membrane receptor > family a g protein-coupled receptor > small molecule receptor (family a gpcr) > monoamine receptor > serotonin receptor

Target Components

Component Description Relationship Accession
5-hydroxytryptamine receptor 1A SINGLE PROTEIN Q64264

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

GO Cellular Component GO:0005886 (plasma membrane)
GO:0005887 (integral component of plasma membrane)
GO:0016020 (membrane)
GO:0016021 (integral component of membrane)
GO Molecular Function GO:0004871 (signal transducer activity)
GO:0004930 (G-protein coupled receptor activity)
GO:0004993 (G-protein coupled serotonin receptor activity)
GO Biological Process GO:0001662 (behavioral fear response)
GO:0007165 (signal transduction)
GO:0007186 (G-protein coupled receptor signaling pathway)
GO:0007198 (adenylate cyclase-inhibiting serotonin receptor signaling pathway)
GO:0007210 (serotonin receptor signaling pathway)
GO:0007610 (behavior)
GO:0008283 (cell proliferation)
GO:0014062 (regulation of serotonin secretion)
GO:0035640 (exploration behavior)
GO:0042053 (regulation of dopamine metabolic process)
GO:0042310 (vasoconstriction)
GO:0042428 (serotonin metabolic process)
GO:0046883 (regulation of hormone secretion)
GO:0050795 (regulation of behavior)

Target Cross References - Protein

MICAD NBK23137 (5-HT1A receptors)
NBK23250 (5-HT1A serotonin receptors)
NBK23263 (5-HT1A receptors)
NBK23391 (5-HT1A receptors)
Reactome R-MMU-390666 (Serotonin receptors.)
R-MMU-418594 (G alpha (i) signalling events.)
UniProt Q60956 Q61617 Q64264 Q8BGS4

Target Cross References - Domain

InterPro IPR000276 (GPCR_Rhodpsn.)
IPR000610 (5HT1A_rcpt.)
IPR002231 (5HT_rcpt.)
IPR017452 (GPCR_Rhodpsn_7TM.)
Pfam PF00001 (7tm_1)
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