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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL3736
Target Type SINGLE PROTEIN
Preferred Name Angiotensin-converting enzyme 2
Synonyms ACE-related carboxypeptidase | ACE2 | ACEH | Angiotensin-converting enzyme 2 | Angiotensin-converting enzyme homolog | Metalloprotease MPROT15 | Processed angiotensin-converting enzyme 2
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme > protease > metallo protease > metallo protease mae clan > metallo protease m2 family

Target Components

Component Description Relationship Accession
Angiotensin-converting enzyme 2 SINGLE PROTEIN Q9BYF1

Target Relations

ChEMBL ID Pref Name Target Type
CHEMBL2096989 Angiotensin-converting enzyme PROTEIN FAMILY

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000130234
Ensembl ENSG00000130234
GO Cellular Component GO:0005576 (extracellular region)
GO:0005615 (extracellular space)
GO:0005737 (cytoplasm)
GO:0005886 (plasma membrane)
GO:0009986 (cell surface)
GO:0016020 (membrane)
GO:0016021 (integral component of membrane)
GO:0045121 (membrane raft)
GO:0070062 (extracellular exosome)
GO Molecular Function GO:0001618 (virus receptor activity)
GO:0001948 (glycoprotein binding)
GO:0004175 (endopeptidase activity)
GO:0004180 (carboxypeptidase activity)
GO:0004181 (metallocarboxypeptidase activity)
GO:0005515 (protein binding)
GO:0008233 (peptidase activity)
GO:0008237 (metallopeptidase activity)
GO:0008241 (peptidyl-dipeptidase activity)
GO:0008270 (zinc ion binding)
GO:0016787 (hydrolase activity)
GO:0046872 (metal ion binding)
GO Biological Process GO:0001817 (regulation of cytokine production)
GO:0002003 (angiotensin maturation)
GO:0002005 (angiotensin catabolic process in blood)
GO:0003051 (angiotensin-mediated drinking behavior)
GO:0003081 (regulation of systemic arterial blood pressure by renin-angiotensin)
GO:0006508 (proteolysis)
GO:0015827 (tryptophan transport)
GO:0016032 (viral process)
GO:0019229 (regulation of vasoconstriction)
GO:0032800 (receptor biosynthetic process)
GO:0042127 (regulation of cell proliferation)
GO:0042312 (regulation of vasodilation)
GO:0046718 (viral entry into host cell)
GO:0046813 (receptor-mediated virion attachment to host cell)
GO:0050727 (regulation of inflammatory response)
GO:0060452 (positive regulation of cardiac muscle contraction)
GO:1903598 (positive regulation of gap junction assembly)
GO:1903779 (regulation of cardiac conduction)
GO:2000379 (positive regulation of reactive oxygen species metabolic process)
Wikipedia Angiotensin-converting_enzyme_2

Target Cross References - Protein

canSAR Q9BYF1
Human Protein Atlas ENSG00000130234
IntAct Q9BYF1
Guide to Pharmacology 1614
Open Targets ENSG00000130234
PharmGKB PA425
Reactome R-HSA-2022377 (Metabolism of Angiotensinogen to Angiotensins.)
UniProt C7ECU1 Q6UWP0 Q86WT0 Q9BYF1 Q9NRA7 Q9UFZ6

Target Cross References - Domain

InterPro IPR001548 (Peptidase_M2.)
IPR031588 (Collectrin_dom.)
IPR033591 (ACE2.)
Pfam PF01401 (Peptidase_M2)
PF16959 (Collectrin)

Target Cross References - Structure

PDBe 1R42 1R4L 2AJF 3D0G 3D0H 3D0I 3KBH 3SCI 3SCJ 3SCK 3SCL
CREDO 1R42 1R4L 2AJF 3D0G 3D0H 3D0I 3KBH 3SCI 3SCJ 3SCK 3SCL
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